Modulation of Orthographic Decoding by Frontal Cortex

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dc.citation.firstpage1173en_US
dc.citation.issueNumber4en_US
dc.citation.journalTitleThe Journal of Neuroscienceen_US
dc.citation.lastpage1184en_US
dc.citation.volumeNumber36en_US
dc.contributor.authorWhaley, Meagan Leeen_US
dc.contributor.authorKadipasaoglu, Cihan Mehmeten_US
dc.contributor.authorCox, Steven Jamesen_US
dc.contributor.authorTandon, Nitinen_US
dc.date.accessioned2016-10-21T18:32:23Z
dc.date.available2016-10-21T18:32:23Z
dc.date.issued2016en_US
dc.description.abstractOpinions are divided on whether word reading processes occur in a hierarchical, feedforward fashion or within an interactive framework. To critically evaluate these competing theories, we recorded electrocorticographic (ECoG) data from 15 human patients with intractable epilepsy during a word completion task and evaluated brain network dynamics across individuals. We used a novel technique of analyzing multihuman ECoG recordings to identify cortical regions most relevant to processing lexical information. The mid fusiform gyrus showed the strongest, earliest response after stimulus onset, whereas activity was maximal in frontal, dorsal lateral prefrontal, and sensorimotor regions toward articulation onset. To evaluate interregional functional connectivity, ECoG data from electrodes situated over specific cortical regions of interest were fit into linear multivariate autoregressive (MVAR) models. Spectral characteristics of the MVAR models were used to precisely reveal the timing and the magnitude of information flow between localized brain regions. This is the first application of MVAR for developing a comprehensive account of interregional interactions from a word reading ECoG dataset. Our comprehensive findings revealed both top-down and bottom-up influences between higher-level language areas and the mid fusiform gyrus. Our findings thus challenge strictly hierarchical, feedforward views of word reading and suggest that orthographic processes are modulated by prefrontal and sensorimotor regions via an interactive framework.en_US
dc.identifier.citationWhaley, Meagan Lee, Kadipasaoglu, Cihan Mehmet, Cox, Steven James, et al.. "Modulation of Orthographic Decoding by Frontal Cortex." <i>The Journal of Neuroscience,</i> 36, no. 4 (2016) Society for Neuroscience: 1173-1184. http://dx.doi.org/10.1523/JNEUROSCI.2985-15.2016.
dc.identifier.doihttp://dx.doi.org/10.1523/JNEUROSCI.2985-15.2016en_US
dc.identifier.urihttps://hdl.handle.net/1911/91988
dc.language.isoengen_US
dc.publisherSociety for Neuroscience
dc.rightsArticle is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
dc.subject.keywordVWFAen_US
dc.subject.keywordelectrocorticographyen_US
dc.subject.keywordintracranial EEGen_US
dc.subject.keywordreadingen_US
dc.subject.keywordsubdural electrodesen_US
dc.subject.keywordwordsen_US
dc.titleModulation of Orthographic Decoding by Frontal Cortexen_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpublisher versionen_US
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