Systems approaches for synthetic biology: a pathway toward mammalian design

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dc.citation.journalTitleFrontiers in Physiologyen_US
dc.citation.volumeNumber4en_US
dc.contributor.authorRekhi, Rahulen_US
dc.contributor.authorQutub, Amina A.en_US
dc.date.accessioned2015-01-08T14:55:03Zen_US
dc.date.available2015-01-08T14:55:03Zen_US
dc.date.issued2013en_US
dc.description.abstractWe review methods of understanding cellular interactions through computation in order to guide the synthetic design of mammalian cells for translational applications, such as regenerative medicine and cancer therapies. In doing so, we argue that the challenges of engineering mammalian cells provide a prime opportunity to leverage advances in computational systems biology. We support this claim systematically, by addressing each of the principal challenges to existing synthetic bioengineering approaches—stochasticity, complexity, and scale—with specific methods and paradigms in systems biology. Moreover, we characterize a key set of diverse computational techniques, including agent-based modeling, Bayesian network analysis, graph theory, and Gillespie simulations, with specific utility toward synthetic biology. Lastly, we examine the mammalian applications of synthetic biology for medicine and health, and how computational systems biology can aid in the continued development of these applications.en_US
dc.identifier.citationRekhi, Rahul and Qutub, Amina A.. "Systems approaches for synthetic biology: a pathway toward mammalian design." <i>Frontiers in Physiology,</i> 4, (2013) Frontiers Media: http://dx.doi.org/10.3389/fphys.2013.00285.en_US
dc.identifier.doihttp://dx.doi.org/10.3389/fphys.2013.00285en_US
dc.identifier.urihttps://hdl.handle.net/1911/78906en_US
dc.language.isoengen_US
dc.publisherFrontiers Mediaen_US
dc.rightsThis is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.en_US
dc.rights.urihttps://creativecommons.org/licenses/by/3.0/en_US
dc.subject.keywordsystems biologyen_US
dc.subject.keywordsynthetic biologyen_US
dc.subject.keywordmammalian cellen_US
dc.subject.keywordcomputational biologyen_US
dc.subject.keywordregenerative medicineen_US
dc.subject.keywordgene circuitsen_US
dc.subject.keywordsignaling networken_US
dc.subject.keywordmultiscale modelingen_US
dc.titleSystems approaches for synthetic biology: a pathway toward mammalian designen_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpublisher versionen_US
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