Diagnostics based on nucleic acid sequence variant profiling: PCR, hybridization, and NGS approaches

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dc.citation.firstpage3en_US
dc.citation.journalTitleAdvanced Drug Delivery Reviewsen_US
dc.citation.lastpage19en_US
dc.citation.volumeNumber105, Part Aen_US
dc.contributor.authorKhodakov, Dmitriyen_US
dc.contributor.authorWang, Chunyanen_US
dc.contributor.authorZhang, David Yuen_US
dc.contributor.orgBioengineeringen_US
dc.date.accessioned2017-01-27T22:23:42Zen_US
dc.date.available2017-01-27T22:23:42Zen_US
dc.date.issued2016en_US
dc.description.abstractNucleic acid sequence variations have been implicated in many diseases, and reliable detection and quantitation of DNA/RNA biomarkers can inform effective therapeutic action, enabling precision medicine. Nucleic acid analysis technologies being translated into the clinic can broadly be classified into hybridization, PCR, and sequencing, as well as their combinations. Here we review the molecular mechanisms of popular commercial assays, and their progress in translation into in vitro diagnostics.en_US
dc.identifier.citationKhodakov, Dmitriy, Wang, Chunyan and Zhang, David Yu. "Diagnostics based on nucleic acid sequence variant profiling: PCR, hybridization, and NGS approaches." <i>Advanced Drug Delivery Reviews,</i> 105, Part A, (2016) Elsevier: 3-19. http://dx.doi.org/10.1016/j.addr.2016.04.005.en_US
dc.identifier.doihttp://dx.doi.org/10.1016/j.addr.2016.04.005en_US
dc.identifier.urihttps://hdl.handle.net/1911/93798en_US
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.rightsThis is an open access article under the CC BY-NC-ND licenseen_US
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/en_US
dc.subject.keywordmolecular diagnosticsen_US
dc.subject.keywordnucleic acid testsen_US
dc.subject.keywordPCRen_US
dc.subject.keywordhybridizationen_US
dc.subject.keywordnext-generation sequencingen_US
dc.titleDiagnostics based on nucleic acid sequence variant profiling: PCR, hybridization, and NGS approachesen_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpublisher versionen_US
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