Diagnostics based on nucleic acid sequence variant profiling: PCR, hybridization, and NGS approaches

Simple item page
dc.citation.firstpage3
dc.citation.journalTitleAdvanced Drug Delivery Reviews
dc.citation.lastpage19
dc.citation.volumeNumber105, Part A
dc.contributor.authorKhodakov, Dmitriy
dc.contributor.authorWang, Chunyan
dc.contributor.authorZhang, David Yu
dc.date.accessioned2017-01-27T22:23:42Z
dc.date.available2017-01-27T22:23:42Z
dc.date.issued2016
dc.description.abstractNucleic acid sequence variations have been implicated in many diseases, and reliable detection and quantitation of DNA/RNA biomarkers can inform effective therapeutic action, enabling precision medicine. Nucleic acid analysis technologies being translated into the clinic can broadly be classified into hybridization, PCR, and sequencing, as well as their combinations. Here we review the molecular mechanisms of popular commercial assays, and their progress in translation into in vitro diagnostics.
dc.identifier.citationKhodakov, Dmitriy, Wang, Chunyan and Zhang, David Yu. "Diagnostics based on nucleic acid sequence variant profiling: PCR, hybridization, and NGS approaches." <i>Advanced Drug Delivery Reviews,</i> 105, Part A, (2016) Elsevier: 3-19. http://dx.doi.org/10.1016/j.addr.2016.04.005.
dc.identifier.doihttp://dx.doi.org/10.1016/j.addr.2016.04.005
dc.identifier.urihttps://hdl.handle.net/1911/93798
dc.language.isoeng
dc.publisherElsevier
dc.rightsThis is an open access article under the CC BY-NC-ND license
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.keywordmolecular diagnostics
dc.subject.keywordnucleic acid tests
dc.subject.keywordPCR
dc.subject.keywordhybridization
dc.subject.keywordnext-generation sequencing
dc.titleDiagnostics based on nucleic acid sequence variant profiling: PCR, hybridization, and NGS approaches
dc.typeJournal article
dc.type.dcmiText
dc.type.publicationpublisher version
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
1-s2.0-S0169409X16301041-main.pdf
Size:
4.21 MB
Format:
Adobe Portable Document Format
Description:
Download
Collections
Faculty Publications
Bioengineering Publications