Gold nanoshell-localized photothermal ablation of prostate tumors in a clinical pilot device study

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dc.citation.firstpage18590en_US
dc.citation.issueNumber37en_US
dc.citation.journalTitleProceedings of the National Academy of Sciencesen_US
dc.citation.lastpage18596en_US
dc.citation.volumeNumber116en_US
dc.contributor.authorRastinehad, Ardeshir R.en_US
dc.contributor.authorAnastos, Harryen_US
dc.contributor.authorWajswol, Ethanen_US
dc.contributor.authorWinoker, Jared S.en_US
dc.contributor.authorSfakianos, John P.en_US
dc.contributor.authorDoppalapudi, Sai K.en_US
dc.contributor.authorCarrick, Michael R.en_US
dc.contributor.authorKnauer, Cynthia J.en_US
dc.contributor.authorTaouli, Bachiren_US
dc.contributor.authorLewis, Sara C.en_US
dc.contributor.authorTewari, Ashutosh K.en_US
dc.contributor.authorSchwartz, Jon A.en_US
dc.contributor.authorCanfield, Steven E.en_US
dc.contributor.authorGeorge, Arvin K.en_US
dc.contributor.authorWest, Jennifer L.en_US
dc.contributor.authorHalas, Naomi J.en_US
dc.date.accessioned2019-11-05T17:29:59Zen_US
dc.date.available2019-11-05T17:29:59Zen_US
dc.date.issued2019en_US
dc.description.abstractBiocompatible gold nanoparticles designed to absorb light at wavelengths of high tissue transparency have been of particular interest for biomedical applications. The ability of such nanoparticles to convert absorbed near-infrared light to heat and induce highly localized hyperthermia has been shown to be highly effective for photothermal cancer therapy, resulting in cell death and tumor remission in a multitude of preclinical animal models. Here we report the initial results of a clinical trial in which laser-excited gold-silica nanoshells (GSNs) were used in combination with magnetic resonance–ultrasound fusion imaging to focally ablate low-intermediate-grade tumors within the prostate. The overall goal is to provide highly localized regional control of prostate cancer that also results in greatly reduced patient morbidity and improved functional outcomes. This pilot device study reports feasibility and safety data from 16 cases of patients diagnosed with low- or intermediate-risk localized prostate cancer. After GSN infusion and high-precision laser ablation, patients underwent multiparametric MRI of the prostate at 48 to 72 h, followed by postprocedure mpMRI/ultrasound targeted fusion biopsies at 3 and 12 mo, as well as a standard 12-core systematic biopsy at 12 mo. GSN-mediated focal laser ablation was successfully achieved in 94% (15/16) of patients, with no significant difference in International Prostate Symptom Score or Sexual Health Inventory for Men observed after treatment. This treatment protocol appears to be feasible and safe in men with low- or intermediate-risk localized prostate cancer without serious complications or deleterious changes in genitourinary function.en_US
dc.identifier.citationRastinehad, Ardeshir R., Anastos, Harry, Wajswol, Ethan, et al.. "Gold nanoshell-localized photothermal ablation of prostate tumors in a clinical pilot device study." <i>Proceedings of the National Academy of Sciences,</i> 116, no. 37 (2019) National Academy of Sciences: 18590-18596. https://doi.org/10.1073/pnas.1906929116.en_US
dc.identifier.digital18590.fullen_US
dc.identifier.doihttps://doi.org/10.1073/pnas.1906929116en_US
dc.identifier.urihttps://hdl.handle.net/1911/107591en_US
dc.language.isoengen_US
dc.publisherNational Academy of Sciencesen_US
dc.rightsThis open access article is distributed under Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND).en_US
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/en_US
dc.titleGold nanoshell-localized photothermal ablation of prostate tumors in a clinical pilot device studyen_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpublisher versionen_US
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