A mobile-phone based high-resolution microendoscope to image cervical precancer

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dc.citation.articleNumbere0211045en_US
dc.citation.issueNumber2en_US
dc.citation.journalTitlePLoS ONEen_US
dc.citation.volumeNumber14en_US
dc.contributor.authorGrant, Benjamin D.en_US
dc.contributor.authorQuang, Timothyen_US
dc.contributor.authorPossati-Resende, Júlio Césaren_US
dc.contributor.authorScapulatempo-Neto, Cristovamen_US
dc.contributor.authorMatsushita, Graziela de Macedoen_US
dc.contributor.authorMauad, Edmundo Carvalhoen_US
dc.contributor.authorStoler, Mark H.en_US
dc.contributor.authorCastle, Philip E.en_US
dc.contributor.authorFregnani, José Humberto Tavares Guerreiroen_US
dc.contributor.authorSchmeler, Kathleen M.en_US
dc.contributor.authorRichards-Kortum, Rebeccaen_US
dc.date.accessioned2019-12-11T15:44:22Zen_US
dc.date.available2019-12-11T15:44:22Zen_US
dc.date.issued2019en_US
dc.description.abstractNearly 90% of cervical cancer cases and deaths occur in low- and middle-income countries that lack comprehensive national HPV immunization and cervical cancer screening programs. In these settings, it is difficult to implement screening programs due to a lack of infrastructure and shortage of trained personnel. Screening programs based on visual inspection with acetic acid (VIA) have been successfully implemented in some low-resource settings. However, VIA has poor specificity and up to 90% of patients receiving treatment based on a positive VIA exam are over-treated. A number of studies have suggested that high-resolution cervical imaging to visualize nuclear morphology in vivo can improve specificity by better distinguishing precancerous and benign lesions. To enable high-resolution imaging in low-resource settings, we developed a portable, low-cost, high-resolution microendoscope that uses a mobile phone to detect and display images of cervical epithelium in vivo with subcellular resolution. The device was fabricated for less than $2,000 using commercially available optical components including filters, an LED and triplet lenses assembled in a 3D-printed opto-mechanical mount. We show that the mobile high-resolution microendoscope achieves similar resolution and signal-to-background ratio as previously reported high-resolution microendoscope systems using traditional cameras and computers to detect and display images. Finally, we demonstrate the ability of the mobile high-resolution microendoscope to image normal and precancerous squamous epithelium of the cervix in vivo in a gynecological referral clinic in Barretos, Brazil.en_US
dc.identifier.citationGrant, Benjamin D., Quang, Timothy, Possati-Resende, Júlio César, et al.. "A mobile-phone based high-resolution microendoscope to image cervical precancer." <i>PLoS ONE,</i> 14, no. 2 (2019) Public Library of Science: https://doi.org/10.1371/journal.pone.0211045.en_US
dc.identifier.digitaljournal.pone.0211045en_US
dc.identifier.doihttps://doi.org/10.1371/journal.pone.0211045en_US
dc.identifier.urihttps://hdl.handle.net/1911/107849en_US
dc.language.isoengen_US
dc.publisherPublic Library of Scienceen_US
dc.rightsThis is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.en_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en_US
dc.titleA mobile-phone based high-resolution microendoscope to image cervical precanceren_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpublisher versionen_US
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