Antioxidant Carbon Particles Improve Cerebrovascular Dysfunction Following Traumatic Brain Injury

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dc.citation.firstpage8007en_US
dc.citation.issueNumber9en_US
dc.citation.journalTitleACS Nanoen_US
dc.citation.lastpage8014en_US
dc.citation.volumeNumber6en_US
dc.contributor.authorBitner, Brittany R.en_US
dc.contributor.authorMarcano, Daniela C.en_US
dc.contributor.authorBerlin, Jacob M.en_US
dc.contributor.authorFabian, Roderic H.en_US
dc.contributor.authorCherian, Leelaen_US
dc.contributor.authorCulver, James C.en_US
dc.contributor.authorDickinson, Mary E.en_US
dc.contributor.authorRobertson, Claudia S.en_US
dc.contributor.authorPautler, Robia G.en_US
dc.contributor.authorKent, Thomas A.en_US
dc.contributor.authorTour, James M.en_US
dc.contributor.orgSmalley Institute for Nanoscale Science and Technologyen_US
dc.date.accessioned2016-06-27T14:14:27Zen_US
dc.date.available2016-06-27T14:14:27Zen_US
dc.date.issued2012en_US
dc.description.abstractInjury to the neurovasculature is a feature of brain injury and must be addressed to maximize opportunity for improvement. Cerebrovascular dysfunction, manifested by reduction in cerebral blood flow (CBF), is a key factor that worsens outcome after traumatic brain injury (TBI), most notably under conditions of hypotension. We report here that a new class of antioxidants, poly(ethylene glycol)-functionalized hydrophilic carbon clusters (PEG-HCCs), which are nontoxic carbon particles, rapidly restore CBF in a mild TBI/hypotension/resuscitation rat model when administered during resuscitation--a clinically relevant time point. Along with restoration of CBF, there is a concomitant normalization of superoxide and nitric oxide levels. Given the role of poor CBF in determining outcome, this finding is of major importance for improving patient health under clinically relevant conditions during resuscitative care, and it has direct implications for the current TBI/hypotension war-fighter victims in the Afghanistan and Middle East theaters. The results also have relevancy in other related acute circumstances such as stroke and organ transplantation.en_US
dc.identifier.citationBitner, Brittany R., Marcano, Daniela C., Berlin, Jacob M., et al.. "Antioxidant Carbon Particles Improve Cerebrovascular Dysfunction Following Traumatic Brain Injury." <i>ACS Nano,</i> 6, no. 9 (2012) American Chemical Society: 8007-8014. http://dx.doi.org/10.1021/nn302615f.en_US
dc.identifier.doihttp://dx.doi.org/10.1021/nn302615fen_US
dc.identifier.urihttps://hdl.handle.net/1911/90570en_US
dc.language.isoengen_US
dc.publisherAmerican Chemical Societyen_US
dc.rightsThis is an author's peer-reviewed final manuscript, as accepted by the publisher. The published article is copyrighted by the American Chemical Society.en_US
dc.titleAntioxidant Carbon Particles Improve Cerebrovascular Dysfunction Following Traumatic Brain Injuryen_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpost-printen_US
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