Embracing heterogeneity: coalescing the Tree of Life and the future of phylogenomics

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dc.citation.articleNumbere6399
dc.citation.journalTitlePeerJ
dc.citation.volumeNumber7
dc.contributor.authorBravo, Gustavo A.
dc.contributor.authorAntonelli, Alexandre
dc.contributor.authorBacon, Christine D.
dc.contributor.authorBartoszek, Krzysztof
dc.contributor.authorBlom, Mozes P.K.
dc.contributor.authorHuynh, Stella
dc.contributor.authorJones, Graham
dc.contributor.authorKnowles, L. Lacey
dc.contributor.authorLamichhaney, Sangeet
dc.contributor.authorMarcussen, Thomas
dc.contributor.authorMorlon, Hélène
dc.contributor.authorNakhleh, Luay K.
dc.contributor.authorOxelman, Bengt
dc.contributor.authorPfeil, Bernard
dc.contributor.authorSchliep, Alexander
dc.contributor.authorWahlberg, Niklas
dc.contributor.authorWerneck, Fernanda P.
dc.contributor.authorWiedenhoeft, John
dc.contributor.authorWillows-Munro, Sandi
dc.contributor.authorEdwards, Scott V.
dc.date.accessioned2019-12-12T17:25:37Z
dc.date.available2019-12-12T17:25:37Z
dc.date.issued2019
dc.description.abstractBuilding the Tree of Life (ToL) is a major challenge of modern biology, requiring advances in cyberinfrastructure, data collection, theory, and more. Here, we argue that phylogenomics stands to benefit by embracing the many heterogeneous genomic signals emerging from the first decade of large-scale phylogenetic analysis spawned by high-throughput sequencing (HTS). Such signals include those most commonly encountered in phylogenomic datasets, such as incomplete lineage sorting, but also those reticulate processes emerging with greater frequency, such as recombination and introgression. Here we focus specifically on how phylogenetic methods can accommodate the heterogeneity incurred by such population genetic processes; we do not discuss phylogenetic methods that ignore such processes, such as concatenation or supermatrix approaches or supertrees. We suggest that methods of data acquisition and the types of markers used in phylogenomics will remain restricted until a posteriori methods of marker choice are made possible with routine whole-genome sequencing of taxa of interest. We discuss limitations and potential extensions of a model supporting innovation in phylogenomics today, the multispecies coalescent model (MSC). Macroevolutionary models that use phylogenies, such as character mapping, often ignore the heterogeneity on which building phylogenies increasingly rely and suggest that assimilating such heterogeneity is an important goal moving forward. Finally, we argue that an integrative cyberinfrastructure linking all steps of the process of building the ToL, from specimen acquisition in the field to publication and tracking of phylogenomic data, as well as a culture that values contributors at each step, are essential for progress.
dc.identifier.citationBravo, Gustavo A., Antonelli, Alexandre, Bacon, Christine D., et al.. "Embracing heterogeneity: coalescing the Tree of Life and the future of phylogenomics." <i>PeerJ,</i> 7, (2019) PeerJ: https://doi.org/10.7717/peerj.6399.
dc.identifier.digitalpeerj-07-6399
dc.identifier.doihttps://doi.org/10.7717/peerj.6399
dc.identifier.urihttps://hdl.handle.net/1911/107887
dc.language.isoeng
dc.publisherPeerJ
dc.rightsDistributed under Creative Commons CC-BY 4.0
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.titleEmbracing heterogeneity: coalescing the Tree of Life and the future of phylogenomics
dc.typeJournal article
dc.type.dcmiText
dc.type.publicationpublisher version
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