Development and characterization of a low intensity vibrational system for microgravity studies

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dc.citation.articleNumber107en_US
dc.citation.journalTitlenpj Microgravityen_US
dc.citation.volumeNumber10en_US
dc.contributor.authorKhan, Omor M.en_US
dc.contributor.authorGasperini, Willen_US
dc.contributor.authorNecessary, Chessen_US
dc.contributor.authorJacobs, Zachen_US
dc.contributor.authorPerry, Samen_US
dc.contributor.authorRexroat, Jasonen_US
dc.contributor.authorNelson, Kendallen_US
dc.contributor.authorGamble, Paulen_US
dc.contributor.authorClements, Twymanen_US
dc.contributor.authorDeLeon, Maximilienen_US
dc.contributor.authorHoward, Seanen_US
dc.contributor.authorZavala, Anamariaen_US
dc.contributor.authorFarach-Carson, Maryen_US
dc.contributor.authorBlaber, Elizabethen_US
dc.contributor.authorWu, Danielleen_US
dc.contributor.authorSatici, Aykuten_US
dc.contributor.authorUzer, Gunesen_US
dc.date.accessioned2025-01-09T20:17:04Zen_US
dc.date.available2025-01-09T20:17:04Zen_US
dc.date.issued2024en_US
dc.description.abstractExtended-duration human spaceflight necessitates a better understanding of the physiological impacts of microgravity. While the ground-based microgravity simulations identified low intensity vibration (LIV) as a possible countermeasure, how cells may respond to LIV under real microgravity remain unexplored. In this way, adaptation of LIV bioreactors for space remains limited, resulting in a significant gap in microgravity research. In this study, we introduce an LIV bioreactor designed specifically for the usage in the International Space Station. Our research covers the bioreactor’s design process and evaluation of the short-term viability of cells encapsulated in hydrogel-laden 3D printed scaffolds under 0.7 g, 90 Hz LIV. An LIV bioreactor compatible with the operation requirements of space missions provides a robust platform to study cellular effects of LIV under real microgravity conditions.en_US
dc.identifier.citationKhan, O. M., Gasperini, W., Necessary, C., Jacobs, Z., Perry, S., Rexroat, J., Nelson, K., Gamble, P., Clements, T., DeLeon, M., Howard, S., Zavala, A., Farach-Carson, M., Blaber, E., Wu, D., Satici, A., & Uzer, G. (2024). Development and characterization of a low intensity vibrational system for microgravity studies. Npj Microgravity, 10(1), 1–9. https://doi.org/10.1038/s41526-024-00444-xen_US
dc.identifier.digitals41526-024-00444-xen_US
dc.identifier.doihttps://doi.org/10.1038/s41526-024-00444-xen_US
dc.identifier.urihttps://hdl.handle.net/1911/118145en_US
dc.language.isoengen_US
dc.publisherSpringer Natureen_US
dc.rightsExcept where otherwise noted, this work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND) license. Permission to reuse, publish, or reproduce the work beyond the terms of the license or beyond the bounds of fair use or other exemptions to copyright law must be obtained from the copyright holder.en_US
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/en_US
dc.titleDevelopment and characterization of a low intensity vibrational system for microgravity studiesen_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpublisher versionen_US
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