Operating principles of Notch–Delta–Jagged module of cell–cell communication

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dc.citation.firstpage55021en_US
dc.citation.journalTitleNew Journal of Physicsen_US
dc.citation.volumeNumber17en_US
dc.contributor.authorJolly, Mohit Kumaren_US
dc.contributor.authorBoareto, Marceloen_US
dc.contributor.authorLu, Mingyangen_US
dc.contributor.authorOnuchic, José Nelsonen_US
dc.contributor.authorClementi, Ceciliaen_US
dc.contributor.authorBen-Jacob, Eshelen_US
dc.contributor.orgBioengineeringen_US
dc.contributor.orgBiosciencesen_US
dc.contributor.orgChemistryen_US
dc.contributor.orgPhysics and Astronomyen_US
dc.contributor.orgCenter for Theoretical Biological Physicsen_US
dc.date.accessioned2015-07-09T15:30:03Zen_US
dc.date.available2015-07-09T15:30:03Zen_US
dc.date.issued2015en_US
dc.description.abstractNotch pathway is an evolutionarily conserved cell–cell communication mechanism governing cell-fate during development and tumor progression. It is activated when Notch receptor of one cell binds to either of its ligand—Delta or Jagged—of another cell. Notch–Delta (ND) signaling forms a two-way switch, and two cells interacting via ND signaling adopt different fates—Sender (high ligand, low receptor) and Receiver (low ligand, high receptor). Notch–Delta–Jagged signaling (NDJ) behaves as a three-way switch and enables an additional fate—hybrid Sender/Receiver (S/R) (medium ligand, medium receptor). Here, by extending our framework of NDJ signaling for a two-cell system, we show that higher production rate of Jagged, but not that of Delta, expands the range of parameters for which both cells attain the hybrid S/R state. Conversely, glycosyltransferase Fringe and cis-inhibition reduces this range of conditions, and reduces the relative stability of the hybrid S/R state, thereby promoting cell-fate divergence and consequently lateral inhibition-based patterns. Lastly, soluble Jagged drives the cells to attain the hybrid S/R state, and soluble Delta drives them to be Receivers. We also discuss the critical role of hybrid S/R state in promoting cancer metastasis by enabling collective cell migration and expanding cancer stem cell (CSC) population.en_US
dc.identifier.citationJolly, Mohit Kumar, Boareto, Marcelo, Lu, Mingyang, et al.. "Operating principles of Notch–Delta–Jagged module of cell–cell communication." <i>New Journal of Physics,</i> 17, (2015) IOP Publishing: 55021. http://dx.doi.org/10.1088/1367-2630/17/5/055021.en_US
dc.identifier.doihttp://dx.doi.org/10.1088/1367-2630/17/5/055021en_US
dc.identifier.urihttps://hdl.handle.net/1911/80851en_US
dc.language.isoengen_US
dc.publisherIOP Publishingen_US
dc.rightsContent from this work may be used under the terms of the Creative Commons Attribution 3.0 licenceen_US
dc.rights.urihttps://creativecommons.org/licenses/by/3.0/en_US
dc.titleOperating principles of Notch–Delta–Jagged module of cell–cell communicationen_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpublisher versionen_US
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