Exploring the Relation between Contextual Social Determinants of Health and COVID-19 Occurrence and Hospitalization

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dc.citation.articleNumber4
dc.citation.issueNumber1
dc.citation.journalTitleInformatics
dc.citation.volumeNumber11
dc.contributor.authorChen, Aokun
dc.contributor.authorZhao, Yunpeng
dc.contributor.authorZheng, Yi
dc.contributor.authorHu, Hui
dc.contributor.authorHu, Xia
dc.contributor.authorFishe, Jennifer N.
dc.contributor.authorHogan, William R.
dc.contributor.authorShenkman, Elizabeth A.
dc.contributor.authorGuo, Yi
dc.contributor.authorBian, Jiang
dc.date.accessioned2024-07-25T20:55:16Z
dc.date.available2024-07-25T20:55:16Z
dc.date.issued2024
dc.description.abstractIt is prudent to take a unified approach to exploring how contextual social determinants of health (SDoH) relate to COVID-19 occurrence and outcomes. Poor geographically represented data and a small number of contextual SDoH examined in most previous research studies have left a knowledge gap in the relationships between contextual SDoH and COVID-19 outcomes. In this study, we linked 199 contextual SDoH factors covering 11 domains of social and built environments with electronic health records (EHRs) from a large clinical research network (CRN) in the National Patient-Centered Clinical Research Network (PCORnet) to explore the relation between contextual SDoH and COVID-19 occurrence and hospitalization. We identified 15,890 COVID-19 patients and 63,560 matched non-COVID-19 patients in Florida between January 2020 and May 2021. We adopted a two-phase multiple linear regression approach modified from that in the exposome-wide association (ExWAS) study. After removing the highly correlated SDoH variables, 86 contextual SDoH variables were included in the data analysis. Adjusting for race, ethnicity, and comorbidities, we found six contextual SDoH variables (i.e., hospital available beds and utilization, percent of vacant property, number of golf courses, and percent of minority) related to the occurrence of COVID-19, and three variables (i.e., farmers market, low access, and religion) related to the hospitalization of COVID-19. To our best knowledge, this is the first study to explore the relationship between contextual SDoH and COVID-19 occurrence and hospitalization using EHRs in a major PCORnet CRN. As an exploratory study, the causal effect of SDoH on COVID-19 outcomes will be evaluated in future studies.
dc.identifier.citationChen, A., Zhao, Y., Zheng, Y., Hu, H., Hu, X., Fishe, J. N., Hogan, W. R., Shenkman, E. A., Guo, Y., & Bian, J. (2024). Exploring the Relation between Contextual Social Determinants of Health and COVID-19 Occurrence and Hospitalization. Informatics, 11(1), Article 1. https://doi.org/10.3390/informatics11010004
dc.identifier.digitalinformatics-11-00004
dc.identifier.doihttps://doi.org/10.3390/informatics11010004
dc.identifier.urihttps://hdl.handle.net/1911/117513
dc.language.isoeng
dc.publisherMDPI
dc.rightsExcept where otherwise noted, this work is licensed under a Creative Commons Attribution (CC BY) license.  Permission to reuse, publish, or reproduce the work beyond the terms of the license or beyond the bounds of fair use or other exemptions to copyright law must be obtained from the copyright holder.
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.titleExploring the Relation between Contextual Social Determinants of Health and COVID-19 Occurrence and Hospitalization
dc.typeJournal article
dc.type.dcmiText
dc.type.publicationpublisher version
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