Endogenous viral elements reveal associations between a non-retroviral RNA virus and symbiotic dinoflagellate genomes

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dc.citation.articleNumber566en_US
dc.citation.journalTitleCommunications Biologyen_US
dc.citation.volumeNumber6en_US
dc.contributor.authorVeglia, Alex J.en_US
dc.contributor.authorBistolas, Kalia S. I.en_US
dc.contributor.authorVoolstra, Christian R.en_US
dc.contributor.authorHume, Benjamin C. C.en_US
dc.contributor.authorRuscheweyh, Hans-Joachimen_US
dc.contributor.authorPlanes, Sergeen_US
dc.contributor.authorAllemand, Denisen_US
dc.contributor.authorBoissin, Emilieen_US
dc.contributor.authorWincker, Patricken_US
dc.contributor.authorPoulain, Julieen_US
dc.contributor.authorMoulin, Clémentineen_US
dc.contributor.authorBourdin, Guillaumeen_US
dc.contributor.authorIwankow, Guillaumeen_US
dc.contributor.authorRomac, Sarahen_US
dc.contributor.authorAgostini, Sylvainen_US
dc.contributor.authorBanaigs, Bernarden_US
dc.contributor.authorBoss, Emmanuelen_US
dc.contributor.authorBowler, Chrisen_US
dc.contributor.authorde Vargas, Colombanen_US
dc.contributor.authorDouville, Ericen_US
dc.contributor.authorFlores, Michelen_US
dc.contributor.authorForcioli, Didieren_US
dc.contributor.authorFurla, Paolaen_US
dc.contributor.authorGaland, Pierre E.en_US
dc.contributor.authorGilson, Ericen_US
dc.contributor.authorLombard, Fabienen_US
dc.contributor.authorPesant, Stéphaneen_US
dc.contributor.authorReynaud, Stéphanieen_US
dc.contributor.authorSunagawa, Shinichien_US
dc.contributor.authorThomas, Olivier P.en_US
dc.contributor.authorTroublé, Romainen_US
dc.contributor.authorZoccola, Didieren_US
dc.contributor.authorCorrea, Adrienne M. S.en_US
dc.contributor.authorVega Thurber, Rebecca L.en_US
dc.date.accessioned2023-07-21T16:14:08Zen_US
dc.date.available2023-07-21T16:14:08Zen_US
dc.date.issued2023en_US
dc.description.abstractEndogenous viral elements (EVEs) offer insight into the evolutionary histories and hosts of contemporary viruses. This study leveraged DNA metagenomics and genomics to detect and infer the host of a non-retroviral dinoflagellate-infecting +ssRNA virus (dinoRNAV) common in coral reefs. As part of the Tara Pacific Expedition, this study surveyed 269 newly sequenced cnidarians and their resident symbiotic dinoflagellates (Symbiodiniaceae), associated metabarcodes, and publicly available metagenomes, revealing 178 dinoRNAV EVEs, predominantly among hydrocoral-dinoflagellate metagenomes. Putative associations between Symbiodiniaceae and dinoRNAV EVEs were corroborated by the characterization of dinoRNAV-like sequences in 17 of 18 scaffold-scale and one chromosome-scale dinoflagellate genome assembly, flanked by characteristically cellular sequences and in proximity to retroelements, suggesting potential mechanisms of integration. EVEs were not detected in dinoflagellate-free (aposymbiotic) cnidarian genome assemblies, including stony corals, hydrocorals, jellyfish, or seawater. The pervasive nature of dinoRNAV EVEs within dinoflagellate genomes (especially Symbiodinium), as well as their inconsistent within-genome distribution and fragmented nature, suggest ancestral or recurrent integration of this virus with variable conservation. Broadly, these findings illustrate how +ssRNA viruses may obscure their genomes as members of nested symbioses, with implications for host evolution, exaptation, and immunity in the context of reef health and disease.en_US
dc.identifier.citationVeglia, Alex J., Bistolas, Kalia S. I., Voolstra, Christian R., et al.. "Endogenous viral elements reveal associations between a non-retroviral RNA virus and symbiotic dinoflagellate genomes." <i>Communications Biology,</i> 6, (2023) Springer Nature: https://doi.org/10.1038/s42003-023-04917-9.en_US
dc.identifier.digitals42003-023-04917-9en_US
dc.identifier.doihttps://doi.org/10.1038/s42003-023-04917-9en_US
dc.identifier.urihttps://hdl.handle.net/1911/115019en_US
dc.language.isoengen_US
dc.publisherSpringer Natureen_US
dc.rightsExcept where otherwise noted, this work is licensed under a Creative Commons Attribution (CC BY) license.  Permission to reuse, publish, or reproduce the work beyond the terms of the license or beyond the bounds of Fair Use or other exemptions to copyright law must be obtained from the copyright holder.en_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en_US
dc.titleEndogenous viral elements reveal associations between a non-retroviral RNA virus and symbiotic dinoflagellate genomesen_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpublisher versionen_US
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