High-Resolution Microendoscopy for the Detection of Cervical Neoplasia in Low-Resource Settings

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dc.citation.firstpagee44924
dc.citation.issueNumber9
dc.citation.journalTitlePLoS One
dc.citation.volumeNumber7
dc.contributor.authorQuinn, Mary K.
dc.contributor.authorBubi, Tefo C.
dc.contributor.authorPierce, Mark C.
dc.contributor.authorKayembe, Mukendi K.
dc.contributor.authorRamogola-Masire, Doreen
dc.contributor.authorRichards-Kortum, Rebecca
dc.date.accessioned2013-03-18T21:03:40Z
dc.date.available2013-03-18T21:03:40Z
dc.date.issued2012
dc.description.abstractCervical cancer is the second leading cause of cancer death among women in developing countries. Developing countries often lack infrastructure, cytotechnologists, and pathologists necessary to implement current screening tools. Due to their low cost and ease of interpretation at the point-of-care, optical imaging technologies may serve as an appropriate solution for cervical cancer screening in low resource settings. We have developed a high-resolution optical imaging system, the High Resolution Microendoscope (HRME), which can be used to interrogate clinically suspicious areas with subcellular spatial resolution, revealing changes in nuclear to cytoplasmic area ratio. In this pilot study carried out at the women's clinic of Princess Marina Hospital in Botswana, 52 unique sites were imaged in 26 patients, and the results were compared to histopathology as a reference standard. Quantitative high resolution imaging achieved a sensitivity and specificity of 86% and 87%, respectively, in differentiating neoplastic (≥CIN 2) tissue from non-neoplastic tissue. These results suggest the potential promise of HRME to assist in the detection of cervical neoplasia in low-resource settings.
dc.embargo.termsnone
dc.identifier.citationQuinn, Mary K., Bubi, Tefo C., Pierce, Mark C., et al.. "High-Resolution Microendoscopy for the Detection of Cervical Neoplasia in Low-Resource Settings." <i>PLoS One,</i> 7, no. 9 (2012) Public Library of Science: e44924. http://dx.doi.org/10.1371/journal.pone.0044924.
dc.identifier.doihttp://dx.doi.org/10.1371/journal.pone.0044924
dc.identifier.urihttps://hdl.handle.net/1911/70705
dc.language.isoeng
dc.publisherPublic Library of Science
dc.rightsThis is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.titleHigh-Resolution Microendoscopy for the Detection of Cervical Neoplasia in Low-Resource Settings
dc.typeJournal article
dc.type.dcmiText
dc.type.publicationpublisher version
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