Controlled Angiogenesis in Peptide Nanofiber Composite Hydrogels

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dc.citation.firstpage845
dc.citation.issueNumber9
dc.citation.journalTitleACS Biomaterials Science & Engineering
dc.citation.lastpage854
dc.citation.volumeNumber1
dc.contributor.authorWickremasinghe, Navindee C.
dc.contributor.authorKumar, Vivek A.
dc.contributor.authorShi, Siyu
dc.contributor.authorHartgerink, Jeffrey D.
dc.date.accessioned2017-05-12T15:04:32Z
dc.date.available2017-05-12T15:04:32Z
dc.date.issued2015
dc.description.abstractMultidomain peptide (MDP) nanofibers create scaffolds that can present bioactive cues to promote biological responses. Orthogonal self-assembly of MDPs and growth-factor-loaded liposomes generate supramolecular composite hydrogels. These composites can act as delivery vehicles with time-controlled release. Here we examine the controlled release of placental growth factor-1 (PlGF-1) for its ability to induce angiogenic responses. PlGF-1 was loaded either in MDP matrices or within liposomes bound inside MDP matrices. Scaffolds showed expected rapid infiltration of macrophages. When released through liposomes incorporated in MDP gels (MDP(Lipo)), PlGF-1 modulates HUVEC VEGF receptor activation in vitro and robust vessel formation in vivo. These loaded MDP(Lipo) hydrogels induce a high level of growth-factor-mediated neovascular maturity. MDP(Lipo) hydrogels offer a biocompatible and injectable platform to tailor drug delivery and treat ischemic tissue diseases.
dc.identifier.citationWickremasinghe, Navindee C., Kumar, Vivek A., Shi, Siyu, et al.. "Controlled Angiogenesis in Peptide Nanofiber Composite Hydrogels." <i>ACS Biomaterials Science & Engineering,</i> 1, no. 9 (2015) American Chemical Society: 845-854. http://dx.doi.org/10.1021/acsbiomaterials.5b00210.
dc.identifier.doihttp://dx.doi.org/10.1021/acsbiomaterials.5b00210
dc.identifier.urihttps://hdl.handle.net/1911/94235
dc.language.isoeng
dc.publisherAmerican Chemical Society
dc.rightsThis is an author's peer-reviewed final manuscript, as accepted by the publisher. The published article is copyrighted by the American Chemical Society.
dc.subject.keywordself-assembly
dc.subject.keywordmultidomain peptide
dc.subject.keywordliposomal encapsulation
dc.subject.keywordPlGF-1
dc.subject.keywordcellular infiltration
dc.subject.keywordangiogenesis
dc.titleControlled Angiogenesis in Peptide Nanofiber Composite Hydrogels
dc.typeJournal article
dc.type.dcmiText
dc.type.publicationpost-print
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