Chromosome-length genome assembly of Teladorsagia circumcincta – a globally important helminth parasite in livestock

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dc.citation.articleNumber74en_US
dc.citation.journalTitleBMC Genomicsen_US
dc.citation.volumeNumber24en_US
dc.contributor.authorHassan, Shamshad Ulen_US
dc.contributor.authorChua, Eng Guanen_US
dc.contributor.authorPaz, Erwin A.en_US
dc.contributor.authorTay, Chin Yenen_US
dc.contributor.authorGreeff, Johan C.en_US
dc.contributor.authorPalmer, Dieter G.en_US
dc.contributor.authorDudchenko, Olgaen_US
dc.contributor.authorAiden, Erez Liebermanen_US
dc.contributor.authorMartin, Graeme B.en_US
dc.contributor.authorKaur, Parwinderen_US
dc.contributor.orgCenter for Theoretical Biological Physicsen_US
dc.date.accessioned2023-03-10T19:04:18Zen_US
dc.date.available2023-03-10T19:04:18Zen_US
dc.date.issued2023en_US
dc.description.abstractGastrointestinal (GIT) helminthiasis is a global problem that affects livestock health, especially in small ruminants. One of the major helminth parasites of sheep and goats, Teladorsagia circumcincta, infects the abomasum and causes production losses, reductions in weight gain, diarrhoea and, in some cases, death in young animals. Control strategies have relied heavily on the use of anthelmintic medication but, unfortunately, T. circumcincta has developed resistance, as have many helminths. Vaccination offers a sustainable and practical solution, but there is no commercially available vaccine to prevent Teladorsagiosis. The discovery of new strategies for controlling T. circumcincta, such as novel vaccine targets and drug candidates, would be greatly accelerated by the availability of better quality, chromosome-length, genome assembly because it would allow the identification of key genetic determinants of the pathophysiology of infection and host-parasite interaction. The available draft genome assembly of T. circumcincta (GCA_002352805.1) is highly fragmented and thus impedes large-scale investigations of population and functional genomics.en_US
dc.identifier.citationHassan, Shamshad Ul, Chua, Eng Guan, Paz, Erwin A., et al.. "Chromosome-length genome assembly of Teladorsagia circumcincta – a globally important helminth parasite in livestock." <i>BMC Genomics,</i> 24, (2023) Springer Nature: https://doi.org/10.1186/s12864-023-09172-0.en_US
dc.identifier.digitals12864-023-09172-0en_US
dc.identifier.doihttps://doi.org/10.1186/s12864-023-09172-0en_US
dc.identifier.urihttps://hdl.handle.net/1911/114511en_US
dc.language.isoengen_US
dc.publisherSpringer Natureen_US
dc.rightsThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.en_US
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/.en_US
dc.titleChromosome-length genome assembly of Teladorsagia circumcincta – a globally important helminth parasite in livestocken_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpublisher versionen_US
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