Noninvasive diagnostic adjuncts for the evaluation of potentially premalignant oral epithelial lesions: current limitations and future directions

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dc.citation.firstpage670en_US
dc.citation.issueNumber6en_US
dc.citation.journalTitleOral Surgery, Oral Medicine, Oral Pathology and Oral Radiologyen_US
dc.citation.lastpage681en_US
dc.citation.volumeNumber125en_US
dc.contributor.authorYang, Eric C.en_US
dc.contributor.authorTan, Melody T.en_US
dc.contributor.authorSchwarz, Richard A.en_US
dc.contributor.authorRichards-Kortum, Rebecca R.en_US
dc.contributor.authorGillenwater, Ann M.en_US
dc.contributor.authorVigneswaran, Nadarajahen_US
dc.contributor.orgBioengineeringen_US
dc.date.accessioned2018-11-15T17:16:11Zen_US
dc.date.available2018-11-15T17:16:11Zen_US
dc.date.issued2018en_US
dc.description.abstractPotentially premalignant oral epithelial lesions (PPOELs) are a group of clinically suspicious conditions, of which a small percentage will undergo malignant transformation. PPOELs are suboptimally diagnosed and managed under the current standard of care. Dysplasia is the most well-established marker to distinguish high-risk PPOELs from low-risk PPOELs, and performing a biopsy to establish dysplasia is the diagnostic gold standard. However, a biopsy is limited by morbidity, resource requirements, and the potential for underdiagnosis. Diagnostic adjuncts may help clinicians better evaluate PPOELs before definitive biopsy, but existing adjuncts, such as toluidine blue, acetowhitening, and autofluorescence imaging, have poor accuracy and are not generally recommended. Recently, in vivo microscopy technologies, such as high-resolution microendoscopy, optical coherence tomography, reflectance confocal microscopy, and multiphoton imaging, have shown promise for improving PPOEL patient care. These technologies allow clinicians to visualize many of the same microscopic features used for histopathologic assessment at the point of care.en_US
dc.identifier.citationYang, Eric C., Tan, Melody T., Schwarz, Richard A., et al.. "Noninvasive diagnostic adjuncts for the evaluation of potentially premalignant oral epithelial lesions: current limitations and future directions." <i>Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology,</i> 125, no. 6 (2018) Elsevier: 670-681. https://doi.org/10.1016/j.oooo.2018.02.020.en_US
dc.identifier.digitaldiagnosticAdjunctsen_US
dc.identifier.doihttps://doi.org/10.1016/j.oooo.2018.02.020en_US
dc.identifier.urihttps://hdl.handle.net/1911/103339en_US
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.rightsThis is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).en_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/en_US
dc.titleNoninvasive diagnostic adjuncts for the evaluation of potentially premalignant oral epithelial lesions: current limitations and future directionsen_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpublisher versionen_US
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