Oxidized Activated Charcoal Nanozymes: Synthesis, and Optimization for In Vitro and In Vivo Bioactivity for Traumatic Brain Injury

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dc.citation.articleNumber2211239en_US
dc.citation.issueNumber10en_US
dc.citation.journalTitleAdvanced Materialsen_US
dc.citation.volumeNumber36en_US
dc.contributor.authorMcHugh, Emily A.en_US
dc.contributor.authorLiopo, Anton V.en_US
dc.contributor.authorMendoza, Kimberlyen_US
dc.contributor.authorRobertson, Claudia S.en_US
dc.contributor.authorWu, Gangen_US
dc.contributor.authorWang, Zheen_US
dc.contributor.authorChen, Weiyinen_US
dc.contributor.authorBeckham, Jacob L.en_US
dc.contributor.authorDerry, Paul J.en_US
dc.contributor.authorKent, Thomas A.en_US
dc.contributor.authorTour, James M.en_US
dc.contributor.orgSmalley-Curl Institute;NanoCarbon Center;Welch Institute for Advanced Materialsen_US
dc.date.accessioned2024-08-29T21:11:44Zen_US
dc.date.available2024-08-29T21:11:44Zen_US
dc.date.issued2024en_US
dc.description.abstractCarbon-based superoxide dismutase (SOD) mimetic nanozymes have recently been employed as promising antioxidant nanotherapeutics due to their distinct properties. The structural features responsible for the efficacy of these nanomaterials as antioxidants are, however, poorly understood. Here, the process–structure–property–performance properties of coconut-derived oxidized activated charcoal (cOAC) nano-SOD mimetics are studied by analyzing how modifications to the nanomaterial's synthesis impact the size, as well as the elemental and electrochemical properties of the particles. These properties are then correlated to the in vitro antioxidant bioactivity of poly(ethylene glycol)-functionalized cOACs (PEG-cOAC). Chemical oxidative treatment methods that afford smaller, more homogeneous cOAC nanoparticles with higher levels of quinone functionalization show enhanced protection against oxidative damage in bEnd.3 murine endothelioma cells. In an in vivo rat model of mild traumatic brain injury (mTBI) and oxidative vascular injury, PEG-cOACs restore cerebral perfusion rapidly to the same extent as the former nanotube-derived PEG-hydrophilic carbon clusters (PEG-HCCs) with a single intravenous injection. These findings provide a deeper understanding of how carbon nanozyme syntheses can be tailored for improved antioxidant bioactivity, and set the stage for translation of medical applications.en_US
dc.identifier.citationMcHugh, E. A., Liopo, A. V., Mendoza, K., Robertson, C. S., Wu, G., Wang, Z., Chen, W., Beckham, J. L., Derry, P. J., Kent, T. A., & Tour, J. M. (2024). Oxidized Activated Charcoal Nanozymes: Synthesis, and Optimization for In Vitro and In Vivo Bioactivity for Traumatic Brain Injury. Advanced Materials, 36(10), 2211239. https://doi.org/10.1002/adma.202211239en_US
dc.identifier.digitalOxidized-Activated-Charcoal-Nanozymesen_US
dc.identifier.doihttps://doi.org/10.1002/adma.202211239en_US
dc.identifier.urihttps://hdl.handle.net/1911/117720en_US
dc.language.isoengen_US
dc.publisherWileyen_US
dc.rightsExcept where otherwise noted, this work is licensed under a Creative Commons Attribution (CC BY) license.  Permission to reuse, publish, or reproduce the work beyond the terms of the license or beyond the bounds of fair use or other exemptions to copyright law must be obtained from the copyright holder.en_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en_US
dc.titleOxidized Activated Charcoal Nanozymes: Synthesis, and Optimization for In Vitro and In Vivo Bioactivity for Traumatic Brain Injuryen_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpublisher versionen_US
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