Theoretical study of active secondary transport: Unexpected differences in molecular mechanisms for antiporters and symporters

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dc.citation.articleNumber085102en_US
dc.citation.journalTitleThe Journal of Chemical Physicsen_US
dc.citation.volumeNumber156en_US
dc.contributor.authorBerlaga, Alexen_US
dc.contributor.authorKolomeisky, Anatoly B.en_US
dc.contributor.orgCenter for Theoretical Biological Physicsen_US
dc.date.accessioned2022-04-18T17:17:29Zen_US
dc.date.available2022-04-18T17:17:29Zen_US
dc.date.issued2022en_US
dc.description.abstractSuccessful functioning of biological cells relies on efficient translocation of different materials across cellular membranes. An important part of this transportation system is membrane channels that are known as antiporters and symporters. They exploit the energy stored as a trans-membrane gradient of one type of molecules to transport the other types of molecules against their gradients. For symporters, the directions of both fluxes for driving and driven species coincide, while for antiporters, the fluxes move in opposite directions. There are surprising experimental observations that despite differing only by the direction of transport fluxes, the molecular mechanisms of translocation adopted by antiporters and symporters seem to be drastically different. We present chemical-kinetic models to quantitatively investigate this phenomenon. Our theoretical approach allows us to explain why antiporters mostly utilize a single-site transportation when only one molecule of any type might be associated with the channel. At the same time, the transport in symporters requires two molecules of different types to be simultaneously associated with the channel. In addition, we investigate the kinetic constraints and efficiency of symporters and compare them with the same properties of antiporters. Our theoretical analysis clarifies some important physical–chemical features of cellular trans-membrane transport.en_US
dc.identifier.citationBerlaga, Alex and Kolomeisky, Anatoly B.. "Theoretical study of active secondary transport: Unexpected differences in molecular mechanisms for antiporters and symporters." <i>The Journal of Chemical Physics,</i> 156, (2022) AIP Publishing LLC: https://doi.org/10.1063/5.0082589.en_US
dc.identifier.doihttps://doi.org/10.1063/5.0082589en_US
dc.identifier.urihttps://hdl.handle.net/1911/112108en_US
dc.language.isoengen_US
dc.publisherAIP Publishing LLCen_US
dc.rightsThis is an author's peer-reviewed final manuscript, as accepted by the publisher. The published article is copyrighted by the authors.en_US
dc.titleTheoretical study of active secondary transport: Unexpected differences in molecular mechanisms for antiporters and symportersen_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpost-printen_US
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