Enabling in vivo measurements of nanoparticle concentrations with three-dimensional optoacoustic tomography

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dc.citation.firstpage581en_US
dc.citation.issueNumber8en_US
dc.citation.journalTitleJournal of Biophotonicsen_US
dc.citation.lastpage588en_US
dc.citation.volumeNumber7en_US
dc.contributor.authorTsyboulski, Dmitri A.en_US
dc.contributor.authorLiopo, Anton V.en_US
dc.contributor.authorSu, Richarden_US
dc.contributor.authorErmilov, Sergey A.en_US
dc.contributor.authorBachilo, Sergei M.en_US
dc.contributor.authorWeisman, R. Bruceen_US
dc.contributor.authorOraevsky, Alexander A.en_US
dc.date.accessioned2017-08-17T19:19:41Zen_US
dc.date.available2017-08-17T19:19:41Zen_US
dc.date.issued2014en_US
dc.description.abstractIn this report, we demonstrate the feasibility of using optoacoustic tomography (OAT) to evaluate biodistributions of nanoparticles in animal models. The redistribution of single-walled carbon nanotubes (SWCNTs) was visualized in living mice. Nanoparticle concentrations in harvested organs were measured spectroscopically using the intrinsic optical absorption and fluorescence of SWCNTs. Observed increases in optoacoustic signal brightness in tissues were compared with increases in optical absorption coefficients caused by SWCNT accumulation. The methodology presented in this report can further be extended to calibrate the sensitivity of an optoacoustic imaging system for a range of changes in optical absorption coefficient values at specific locations or organs in a mouse body to enable noninvasive measurements of nanoparticle concentrations in vivo. Additionally, qualitative information provided by OAT and quantitative information obtained ex vivo may provide valuable feedback for advancing methods of quantitative analysis with OAT.en_US
dc.identifier.citationTsyboulski, Dmitri A., Liopo, Anton V., Su, Richard, et al.. "Enabling in vivo measurements of nanoparticle concentrations with three-dimensional optoacoustic tomography." <i>Journal of Biophotonics,</i> 7, no. 8 (2014) Wiley: 581-588. https://doi.org/10.1002/jbio.201200233.en_US
dc.identifier.digitalEnabling_in-vivo_measurements_nanoparticle_concentrationsen_US
dc.identifier.doihttps://doi.org/10.1002/jbio.201200233en_US
dc.identifier.urihttps://hdl.handle.net/1911/97335en_US
dc.language.isoengen_US
dc.publisherWileyen_US
dc.rightsThis is an author's peer-reviewed final manuscript, as accepted by the publisher. The published article is copyrighted by Wiley.en_US
dc.subject.keywordSWCNTen_US
dc.subject.keywordbiodistributionen_US
dc.subject.keywordcarbon nanotubesen_US
dc.subject.keywordnanoparticle concentrationen_US
dc.subject.keywordoptoacoustic tomographyen_US
dc.subject.keywordphotoacoustic imagingen_US
dc.titleEnabling in vivo measurements of nanoparticle concentrations with three-dimensional optoacoustic tomographyen_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpost-printen_US
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