Enabling in vivo measurements of nanoparticle concentrations with three-dimensional optoacoustic tomography

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dc.citation.firstpage581
dc.citation.issueNumber8
dc.citation.journalTitleJournal of Biophotonics
dc.citation.lastpage588
dc.citation.volumeNumber7
dc.contributor.authorTsyboulski, Dmitri A.
dc.contributor.authorLiopo, Anton V.
dc.contributor.authorSu, Richard
dc.contributor.authorErmilov, Sergey A.
dc.contributor.authorBachilo, Sergei M.
dc.contributor.authorWeisman, R. Bruce
dc.contributor.authorOraevsky, Alexander A.
dc.date.accessioned2017-08-17T19:19:41Z
dc.date.available2017-08-17T19:19:41Z
dc.date.issued2014
dc.description.abstractIn this report, we demonstrate the feasibility of using optoacoustic tomography (OAT) to evaluate biodistributions of nanoparticles in animal models. The redistribution of single-walled carbon nanotubes (SWCNTs) was visualized in living mice. Nanoparticle concentrations in harvested organs were measured spectroscopically using the intrinsic optical absorption and fluorescence of SWCNTs. Observed increases in optoacoustic signal brightness in tissues were compared with increases in optical absorption coefficients caused by SWCNT accumulation. The methodology presented in this report can further be extended to calibrate the sensitivity of an optoacoustic imaging system for a range of changes in optical absorption coefficient values at specific locations or organs in a mouse body to enable noninvasive measurements of nanoparticle concentrations in vivo. Additionally, qualitative information provided by OAT and quantitative information obtained ex vivo may provide valuable feedback for advancing methods of quantitative analysis with OAT.
dc.identifier.citationTsyboulski, Dmitri A., Liopo, Anton V., Su, Richard, et al.. "Enabling in vivo measurements of nanoparticle concentrations with three-dimensional optoacoustic tomography." <i>Journal of Biophotonics,</i> 7, no. 8 (2014) Wiley: 581-588. https://doi.org/10.1002/jbio.201200233.
dc.identifier.digitalEnabling_in-vivo_measurements_nanoparticle_concentrations
dc.identifier.doihttps://doi.org/10.1002/jbio.201200233
dc.identifier.urihttps://hdl.handle.net/1911/97335
dc.language.isoeng
dc.publisherWiley
dc.rightsThis is an author's peer-reviewed final manuscript, as accepted by the publisher. The published article is copyrighted by Wiley.
dc.subject.keywordSWCNT
dc.subject.keywordbiodistribution
dc.subject.keywordcarbon nanotubes
dc.subject.keywordnanoparticle concentration
dc.subject.keywordoptoacoustic tomography
dc.subject.keywordphotoacoustic imaging
dc.titleEnabling in vivo measurements of nanoparticle concentrations with three-dimensional optoacoustic tomography
dc.typeJournal article
dc.type.dcmiText
dc.type.publicationpost-print
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