Derivatives of uncialamycin, methods of synthesis and their use as antitumor agents

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dc.contributor.assigneeRice Universityen_US
dc.contributor.publisherUnited States Patent and Trademark Officeen_US
dc.creatorNicolaou, Kyriacos C.en_US
dc.creatorLu, Minen_US
dc.creatorMandal, Debashisen_US
dc.creatorGangwar, Sanjeeven_US
dc.creatorChowdari, Naidu Sen_US
dc.creatorPoudel, Yam B.en_US
dc.date.accessioned2017-12-14T19:09:06Zen_US
dc.date.available2017-12-14T19:09:06Zen_US
dc.date.filed2014-08-14en_US
dc.date.issued2017-10-03en_US
dc.description.abstractIn one aspect, the present disclosure provides new analogs of uncialamycin of formulae (I) and (II). The present disclosure also provides novel synthetic pathways to obtaining uncialamycin and analogs thereof. Additionally, the present disclosure also describes methods of use of uncialamycin and analogs thereof. In another aspect, the present disclosure provides antibody-drug conjugates comprising the compounds of formulae (I) and (II).en_US
dc.digitization.specificationsThis patent information was downloaded from the US Patent and Trademark website (http://www.uspto.gov/) as image-PDFs. The PDFs were OCRed for access purposesen_US
dc.format.extent106en_US
dc.identifier.citationNicolaou, Kyriacos C., Lu, Min, Mandal, Debashis, Gangwar, Sanjeev, Chowdari, Naidu S and Poudel, Yam B., "Derivatives of uncialamycin, methods of synthesis and their use as antitumor agents." Patent US9777013B2. issued 2017-10-03. Retrieved from <a href="https://hdl.handle.net/1911/98878">https://hdl.handle.net/1911/98878</a>.en_US
dc.identifier.patentIDUS9777013B2en_US
dc.identifier.urihttps://hdl.handle.net/1911/98878en_US
dc.language.isoengen_US
dc.titleDerivatives of uncialamycin, methods of synthesis and their use as antitumor agentsen_US
dc.typeUtility patenten_US
dc.type.dcmiTexten_US
dc.type.genrepatentsen_US
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