Derivatives of uncialamycin, methods of synthesis and their use as antitumor agents

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dc.contributor.assigneeRice University
dc.contributor.publisherUnited States Patent and Trademark Office
dc.creatorNicolaou, Kyriacos C.
dc.creatorLu, Min
dc.creatorMandal, Debashis
dc.creatorGangwar, Sanjeev
dc.creatorChowdari, Naidu S
dc.creatorPoudel, Yam B.
dc.date.accessioned2017-12-14T19:09:06Z
dc.date.available2017-12-14T19:09:06Z
dc.date.filed2014-08-14
dc.date.issued2017-10-03
dc.description.abstractIn one aspect, the present disclosure provides new analogs of uncialamycin of formulae (I) and (II). The present disclosure also provides novel synthetic pathways to obtaining uncialamycin and analogs thereof. Additionally, the present disclosure also describes methods of use of uncialamycin and analogs thereof. In another aspect, the present disclosure provides antibody-drug conjugates comprising the compounds of formulae (I) and (II).
dc.digitization.specificationsThis patent information was downloaded from the US Patent and Trademark website (http://www.uspto.gov/) as image-PDFs. The PDFs were OCRed for access purposes
dc.format.extent106
dc.identifier.citationNicolaou, Kyriacos C., Lu, Min, Mandal, Debashis, Gangwar, Sanjeev, Chowdari, Naidu S and Poudel, Yam B., "Derivatives of uncialamycin, methods of synthesis and their use as antitumor agents." Patent US9777013B2. issued 2017-10-03. Retrieved from <a href="https://hdl.handle.net/1911/98878">https://hdl.handle.net/1911/98878</a>.
dc.identifier.patentIDUS9777013B2
dc.identifier.urihttps://hdl.handle.net/1911/98878
dc.language.isoeng
dc.titleDerivatives of uncialamycin, methods of synthesis and their use as antitumor agents
dc.typeUtility patent
dc.type.dcmiText
dc.type.genrepatents
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