Relaxivity Enhancement of Aquated Tris(β-diketonate)gadolinium(III) Chelates by Confinement within Ultrashort Single-walled Carbon Nanotubes
| dc.citation.journalTitle | Contrast Media & Molecular Imaging | en_US |
| dc.contributor.author | Law, Justin J. | en_US |
| dc.contributor.author | Guven, Adem | en_US |
| dc.contributor.author | Wilson, Lon J. | en_US |
| dc.contributor.org | Richard E. Smalley Institute for Nanoscale Science and Technology | en_US |
| dc.date.accessioned | 2014-07-31T21:17:57Z | en_US |
| dc.date.available | 2014-07-31T21:17:57Z | en_US |
| dc.date.issued | 2014 | en_US |
| dc.description.abstract | Ultrashort single-walled carbon nanotubes loaded with gadolinium ions (gadonanotubes) have been previously shown to exhibit extremely high T1-weighted relaxivities (>100 mM-1s-1). To further examine the effect of nanoconfinement on the relaxivity of gadolinium based contrast agents for magnetic resonance imaging (MRI), a series of ultrashort single-walled carbon nanotube (US-tube) materials internally loaded with gadolinium chelates has been prepared and studied. US-tubes were loaded with Gd(acac)3ﾷ2H2O, Gd(hfac)3ﾷ2H2O, and Gd(thd)3. (acac = acetylacetone, hfac = hexafluoroacetylacetone, thd = tetramethylheptanedione) The longitudinal relaxivities of the prepared materials determined at 25ﾰC in a 1.5 T field were 103 mM-1s-1 for Gd(acac)3ﾷ2H2O@US-tubes, 105 mM-1s-1 for Gd(hfac)3ﾷ2H2O@US-tubes and 26 mM-1s-1 for Gd(thd)3@US-tubes. Compared to the relaxivities obtained for the unloaded chelates (<10 mM-1s-1) as well as accounting for the T1 reduction observed for the empty US-tubes, the boost in relaxivity for chelate-loaded US-tubes is attributed to confinement within the nanotube and depends on the number of coordinated water molecules. | en_US |
| dc.identifier.citation | Law, Justin J., Guven, Adem and Wilson, Lon J.. "Relaxivity Enhancement of Aquated Tris(β-diketonate)gadolinium(III) Chelates by Confinement within Ultrashort Single-walled Carbon Nanotubes." <i>Contrast Media & Molecular Imaging,</i> (2014) John Wiley & Sons, Inc.: http://dx.doi.org/10.1002/cmmi.1603. | en_US |
| dc.identifier.doi | http://dx.doi.org/10.1002/cmmi.1603 | en_US |
| dc.identifier.uri | https://hdl.handle.net/1911/76312 | en_US |
| dc.language.iso | eng | en_US |
| dc.publisher | John Wiley & Sons, Inc. | en_US |
| dc.rights | This is an author's peer-reviewed final manuscript, as accepted by the publisher. The published article is copyrighted by Wiley. | en_US |
| dc.subject.keyword | MRI | en_US |
| dc.subject.keyword | contrast agent | en_US |
| dc.subject.keyword | relaxivity | en_US |
| dc.subject.keyword | carbon nanotube | en_US |
| dc.subject.keyword | gadolinium | en_US |
| dc.title | Relaxivity Enhancement of Aquated Tris(β-diketonate)gadolinium(III) Chelates by Confinement within Ultrashort Single-walled Carbon Nanotubes | en_US |
| dc.type | Journal article | en_US |
| dc.type.dcmi | Text | en_US |
| dc.type.publication | post-print | en_US |
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