In vivo classification of colorectal neoplasia using high-resolution microendoscopy: Improvement with experience

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dc.citation.firstpage1155en_US
dc.citation.issueNumber7en_US
dc.citation.journalTitleJournal of Gastroenterology and Hepatologyen_US
dc.citation.lastpage1160en_US
dc.citation.volumeNumber30en_US
dc.contributor.authorParikh, Neil D.en_US
dc.contributor.authorPerl, Danielen_US
dc.contributor.authorLee, Michelle H.en_US
dc.contributor.authorChang, Shannon S.en_US
dc.contributor.authorPolydorides, Alexandros D.en_US
dc.contributor.authorMoshier, Erinen_US
dc.contributor.authorGodbold, Jamesen_US
dc.contributor.authorZhou, Elinoren_US
dc.contributor.authorMitcham, Josephineen_US
dc.contributor.authorRichards-Kortum, Rebeccaen_US
dc.contributor.authorAnandasabapathy, Sharmilaen_US
dc.date.accessioned2015-09-24T18:13:01Zen_US
dc.date.available2015-09-24T18:13:01Zen_US
dc.date.issued2015en_US
dc.description.abstractBackground and Aims: High-resolution microendoscopy (HRME) is a novel, low-cost “optical biopsy” technology that allows for subcellular imaging. The study aim was to evaluate the learning curve of HRME for the differentiation of neoplastic from non-neoplastic colorectal polyps. Methods: In a prospective cohort fashion, a total of 162 polyps from 97 patients at a single tertiary care center were imaged by HRME and classified in real time as neoplastic (adenomatous, cancer) or non-neoplastic (normal, hyperplastic, inflammatory). Histopathology was the gold standard for comparison. Diagnostic accuracy was examined at three intervals over time throughout the study; the initial interval included the first 40 polyps, the middle interval included the next 40 polyps examined, and the final interval included the last 82 polyps examined. Results: Sensitivity increased significantly from the initial interval (50%) to the middle interval (94%, P = 0.02) and the last interval (97%, P = 0.01). Similarly, specificity was 69% for the initial interval but increased to 92% (P = 0.07) in the middle interval and 96% (P = 0.02) in the last interval. Overall accuracy was 63% for the initial interval and then improved to 93% (P = 0.003) in the middle interval and 96% (P = 0.0007) in the last interval. Conclusions: In conclusion, this in vivo study demonstrates that an endoscopist without prior colon HRME experience can achieve greater than 90% accuracy for identifying neoplastic colorectal polyps after 40 polyps imaged. HRME is a promising modality to complement white light endoscopy in differentiating neoplastic from non-neoplastic colorectal polyps.en_US
dc.identifier.citationParikh, Neil D., Perl, Daniel, Lee, Michelle H., et al.. "In vivo classification of colorectal neoplasia using high-resolution microendoscopy: Improvement with experience." <i>Journal of Gastroenterology and Hepatology,</i> 30, no. 7 (2015) Wiley: 1155-1160. http://dx.doi.org/10.1111/jgh.12937.en_US
dc.identifier.doihttp://dx.doi.org/10.1111/jgh.12937en_US
dc.identifier.urihttps://hdl.handle.net/1911/81717en_US
dc.language.isoengen_US
dc.publisherWileyen_US
dc.rightsThis is an author's peer-reviewed final manuscript, as accepted by the publisher. The published article is copyrighted by Wiley.en_US
dc.subject.keywordadenoma classificationen_US
dc.subject.keywordcolorectal polypsen_US
dc.subject.keywordmicroendoscopyen_US
dc.titleIn vivo classification of colorectal neoplasia using high-resolution microendoscopy: Improvement with experienceen_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpost-printen_US
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