Development of Morphogen Gradients with Spatially Varying Degradation Rates

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dc.citation.firstpage2745
dc.citation.issueNumber10
dc.citation.journalTitleThe Journal of Physical Chemistry B
dc.citation.lastpage2750
dc.citation.volumeNumber120
dc.contributor.authorTeimouri, Hamid
dc.contributor.authorBozorgui, Behnaz
dc.contributor.authorKolomeisky, Anatoly B.
dc.contributor.orgCenter for Theoretical Biological Physics
dc.date.accessioned2016-03-28T16:35:50Z
dc.date.available2016-03-28T16:35:50Z
dc.date.issued2016
dc.description.abstractSuccessful biological development via spatial and temporal regulations of cell differentiation relies on the action of multiple signaling molecules that are known as morphogens. It is now well established that biological signaling molecules create nonuniform concentration profiles, called morphogen gradients, that activate different genes, leading to patterning in the developing organisms. The current view of the formation of morphogen gradients is that it is a result of complex reaction–diffusion processes that include production, diffusion, and degradation of signaling molecules. Recent studies also suggest that the degradation of morphogens is a critically important step in the whole process. We develop a theoretical model that allows us to investigate the role of a spatially varying degradation in the formation of morphogen gradients. Our analysis shows that the spatial inhomogeneities in degradation might strongly influence the dynamics of formation of signaling profiles. Physical–chemical mechanisms of the underlying processes are discussed.
dc.identifier.citationTeimouri, Hamid, Bozorgui, Behnaz and Kolomeisky, Anatoly B.. "Development of Morphogen Gradients with Spatially Varying Degradation Rates." <i>The Journal of Physical Chemistry B,</i> 120, no. 10 (2016) American Chemical Society: 2745-2750. http://dx.doi.org/10.1021/acs.jpcb.6b00695.
dc.identifier.doihttp://dx.doi.org/10.1021/acs.jpcb.6b00695
dc.identifier.urihttps://hdl.handle.net/1911/88650
dc.language.isoeng
dc.publisherAmerican Chemical Society
dc.rightsThis is an author's peer-reviewed final manuscript, as accepted by the publisher. The published article is copyrighted by the American Chemical Society.
dc.titleDevelopment of Morphogen Gradients with Spatially Varying Degradation Rates
dc.typeJournal article
dc.type.dcmiText
dc.type.publicationpost-print
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