Induction of Mesenchymal-Epithelial Transitions in Sarcoma Cells
Date
2017
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JoVE
Abstract
We present here a cell culture method for inducing mesenchymal-epithelial transitions (MET) in sarcoma cells based on combined ectopic expression of microRNA-200 family members and grainyhead-like 2 (GRHL2). This method is suitable for better understanding the biological impact of phenotypic plasticity on cancer aggressiveness and treatments.
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Ware, Kathryn E., Gilja, Shivee, Xu, Shenghan, et al.. "Induction of Mesenchymal-Epithelial Transitions in Sarcoma Cells." Journal of Visualized Experiments, 122, (2017) JoVE: https://doi.org/10.3791/55520.
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