Advances in 3D bioprinting for regenerative medicine applications

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dc.citation.articleNumberrbae033en_US
dc.citation.journalTitleRegenerative Biomaterialsen_US
dc.citation.volumeNumber11en_US
dc.contributor.authorLoukelis, Konstantinosen_US
dc.contributor.authorKoutsomarkos, Nikosen_US
dc.contributor.authorMikos, Antonios Gen_US
dc.contributor.authorChatzinikolaidou, Mariaen_US
dc.date.accessioned2024-08-02T13:32:10Zen_US
dc.date.available2024-08-02T13:32:10Zen_US
dc.date.issued2024en_US
dc.description.abstractBiofabrication techniques allow for the construction of biocompatible and biofunctional structures composed from biomaterials, cells and biomolecules. Bioprinting is an emerging 3D printing method which utilizes biomaterial-based mixtures with cells and other biological constituents into printable suspensions known as bioinks. Coupled with automated design protocols and based on different modes for droplet deposition, 3D bioprinters are able to fabricate hydrogel-based objects with specific architecture and geometrical properties, providing the necessary environment that promotes cell growth and directs cell differentiation towards application-related lineages. For the preparation of such bioinks, various water-soluble biomaterials have been employed, including natural and synthetic biopolymers, and inorganic materials. Bioprinted constructs are considered to be one of the most promising avenues in regenerative medicine due to their native organ biomimicry. For a successful application, the bioprinted constructs should meet particular criteria such as optimal biological response, mechanical properties similar to the target tissue, high levels of reproducibility and printing fidelity, but also increased upscaling capability. In this review, we highlight the most recent advances in bioprinting, focusing on the regeneration of various tissues including bone, cartilage, cardiovascular, neural, skin and other organs such as liver, kidney, pancreas and lungs. We discuss the rapidly developing co-culture bioprinting systems used to resemble the complexity of tissues and organs and the crosstalk between various cell populations towards regeneration. Moreover, we report on the basic physical principles governing 3D bioprinting, and the ideal bioink properties based on the biomaterials’ regenerative potential. We examine and critically discuss the present status of 3D bioprinting regarding its applicability and current limitations that need to be overcome to establish it at the forefront of artificial organ production and transplantation.en_US
dc.identifier.citationLoukelis, K., Koutsomarkos, N., Mikos, A. G., & Chatzinikolaidou, M. (2024). Advances in 3D bioprinting for regenerative medicine applications. Regenerative Biomaterials, 11, rbae033. https://doi.org/10.1093/rb/rbae033en_US
dc.identifier.digitalrbae033en_US
dc.identifier.doihttps://doi.org/10.1093/rb/rbae033en_US
dc.identifier.urihttps://hdl.handle.net/1911/117579en_US
dc.language.isoengen_US
dc.publisherOxford University Pressen_US
dc.rightsExcept where otherwise noted, this work is licensed under a Creative Commons Attribution (CC BY) license.  Permission to reuse, publish, or reproduce the work beyond the terms of the license or beyond the bounds of fair use or other exemptions to copyright law must be obtained from the copyright holder.en_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en_US
dc.titleAdvances in 3D bioprinting for regenerative medicine applicationsen_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpublisher versionen_US
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