Miniature battery-free epidural cortical stimulators

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dc.citation.articleNumbereadn0858
dc.citation.issueNumber15
dc.citation.journalTitleScience Advances
dc.citation.volumeNumber10
dc.contributor.authorWoods, Joshua E.
dc.contributor.authorSinger, Amanda L.
dc.contributor.authorAlrashdan, Fatima
dc.contributor.authorTan, Wendy
dc.contributor.authorTan, Chunfeng
dc.contributor.authorSheth, Sunil A.
dc.contributor.authorSheth, Sameer A.
dc.contributor.authorRobinson, Jacob T.
dc.contributor.orgApplied Physics Program
dc.date.accessioned2024-07-25T20:55:18Z
dc.date.available2024-07-25T20:55:18Z
dc.date.issued2024
dc.description.abstractMiniaturized neuromodulation systems could improve the safety and reduce the invasiveness of bioelectronic neuromodulation. However, as implantable bioelectronic devices are made smaller, it becomes difficult to store enough power for long-term operation in batteries. Here, we present a battery-free epidural cortical stimulator that is only 9 millimeters in width yet can safely receive enough wireless power using magnetoelectric antennas to deliver 14.5-volt stimulation bursts, which enables it to stimulate cortical activity on-demand through the dura. The device has digitally programmable stimulation output and centimeter-scale alignment tolerances when powered by an external transmitter. We demonstrate that this device has enough power and reliability for real-world operation by showing acute motor cortex activation in human patients and reliable chronic motor cortex activation for 30 days in a porcine model. This platform opens the possibility of simple surgical procedures for precise neuromodulation.
dc.identifier.citationWoods, J. E., Singer, A. L., Alrashdan, F., Tan, W., Tan, C., Sheth, S. A., Sheth, S. A., & Robinson, J. T. (2024). Miniature battery-free epidural cortical stimulators. Science Advances, 10(15), eadn0858. https://doi.org/10.1126/sciadv.adn0858
dc.identifier.digitalsciadv-adn0858
dc.identifier.doihttps://doi.org/10.1126/sciadv.adn0858
dc.identifier.urihttps://hdl.handle.net/1911/117528
dc.language.isoeng
dc.publisherAAAS
dc.rightsExcept where otherwise noted, this work is licensed under a Creative Commons Attribution (CC BY) license.  Permission to reuse, publish, or reproduce the work beyond the terms of the license or beyond the bounds of fair use or other exemptions to copyright law must be obtained from the copyright holder.
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.titleMiniature battery-free epidural cortical stimulators
dc.typeJournal article
dc.type.dcmiText
dc.type.publicationpublisher version
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