Miniature battery-free epidural cortical stimulators

Simple item page
dc.citation.articleNumbereadn0858en_US
dc.citation.issueNumber15en_US
dc.citation.journalTitleScience Advancesen_US
dc.citation.volumeNumber10en_US
dc.contributor.authorWoods, Joshua E.en_US
dc.contributor.authorSinger, Amanda L.en_US
dc.contributor.authorAlrashdan, Fatimaen_US
dc.contributor.authorTan, Wendyen_US
dc.contributor.authorTan, Chunfengen_US
dc.contributor.authorSheth, Sunil A.en_US
dc.contributor.authorSheth, Sameer A.en_US
dc.contributor.authorRobinson, Jacob T.en_US
dc.contributor.orgApplied Physics Programen_US
dc.date.accessioned2024-07-25T20:55:18Zen_US
dc.date.available2024-07-25T20:55:18Zen_US
dc.date.issued2024en_US
dc.description.abstractMiniaturized neuromodulation systems could improve the safety and reduce the invasiveness of bioelectronic neuromodulation. However, as implantable bioelectronic devices are made smaller, it becomes difficult to store enough power for long-term operation in batteries. Here, we present a battery-free epidural cortical stimulator that is only 9 millimeters in width yet can safely receive enough wireless power using magnetoelectric antennas to deliver 14.5-volt stimulation bursts, which enables it to stimulate cortical activity on-demand through the dura. The device has digitally programmable stimulation output and centimeter-scale alignment tolerances when powered by an external transmitter. We demonstrate that this device has enough power and reliability for real-world operation by showing acute motor cortex activation in human patients and reliable chronic motor cortex activation for 30 days in a porcine model. This platform opens the possibility of simple surgical procedures for precise neuromodulation.en_US
dc.identifier.citationWoods, J. E., Singer, A. L., Alrashdan, F., Tan, W., Tan, C., Sheth, S. A., Sheth, S. A., & Robinson, J. T. (2024). Miniature battery-free epidural cortical stimulators. Science Advances, 10(15), eadn0858. https://doi.org/10.1126/sciadv.adn0858en_US
dc.identifier.digitalsciadv-adn0858en_US
dc.identifier.doihttps://doi.org/10.1126/sciadv.adn0858en_US
dc.identifier.urihttps://hdl.handle.net/1911/117528en_US
dc.language.isoengen_US
dc.publisherAAASen_US
dc.rightsExcept where otherwise noted, this work is licensed under a Creative Commons Attribution (CC BY) license.  Permission to reuse, publish, or reproduce the work beyond the terms of the license or beyond the bounds of fair use or other exemptions to copyright law must be obtained from the copyright holder.en_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en_US
dc.titleMiniature battery-free epidural cortical stimulatorsen_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpublisher versionen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
sciadv-adn0858.pdf
Size:
3.55 MB
Format:
Adobe Portable Document Format
Download
Collections
Faculty Publications
Bioengineering Publications
ECE Publications