Gelatin carriers for drug and cell delivery in tissue engineering

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dc.citation.firstpage210en_US
dc.citation.journalTitleJournal of Controlled Releaseen_US
dc.citation.lastpage218en_US
dc.citation.volumeNumber190en_US
dc.contributor.authorSantoro, Marcoen_US
dc.contributor.authorTatara, Alexander M.en_US
dc.contributor.authorMikos, Antonios G.en_US
dc.date.accessioned2015-10-28T19:04:03Zen_US
dc.date.available2015-10-28T19:04:03Zen_US
dc.date.issued2014en_US
dc.description.abstractThe ability of gelatin to form complexes with different drugs has been investigated for controlled release applications. Gelatin parameters, such as crosslinking density and isoelectric point, have been tuned in order to optimize gelatin degradation and drug delivery kinetics. In recent years, focus has shifted away from the use of gelatin in isolation toward the modification of gelatin with functional groups and the fabrication of material composites with embedded gelatin carriers. In this review, we highlight some of the latest work being performed in these areas and comment on trends in the field. Specifically, we discuss gelatin modifications for immune system evasion, drug stabilization, and targeted delivery, as well as gelatin composite systems based on ceramics, naturally-occurring polymers, and synthetic polymers.en_US
dc.identifier.citationSantoro, Marco, Tatara, Alexander M. and Mikos, Antonios G.. "Gelatin carriers for drug and cell delivery in tissue engineering." <i>Journal of Controlled Release,</i> 190, (2014) Elsevier: 210-218. http://dx.doi.org/10.1016/j.jconrel.2014.04.014.en_US
dc.identifier.doihttp://dx.doi.org/10.1016/j.jconrel.2014.04.014en_US
dc.identifier.urihttps://hdl.handle.net/1911/81939en_US
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.rightsThis is an author's peer-reviewed final manuscript, as accepted by the publisher. The published article is copyrighted by Elsevier.en_US
dc.subject.keywordgelatinen_US
dc.subject.keyworddrug deliveryen_US
dc.subject.keywordcell deliveryen_US
dc.subject.keywordcontrolled releaseen_US
dc.subject.keywordcomposite materialen_US
dc.titleGelatin carriers for drug and cell delivery in tissue engineeringen_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpost-printen_US
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