Gelatin carriers for drug and cell delivery in tissue engineering

Simple item page
dc.citation.firstpage210
dc.citation.journalTitleJournal of Controlled Release
dc.citation.lastpage218
dc.citation.volumeNumber190
dc.contributor.authorSantoro, Marco
dc.contributor.authorTatara, Alexander M.
dc.contributor.authorMikos, Antonios G.
dc.date.accessioned2015-10-28T19:04:03Z
dc.date.available2015-10-28T19:04:03Z
dc.date.issued2014
dc.description.abstractThe ability of gelatin to form complexes with different drugs has been investigated for controlled release applications. Gelatin parameters, such as crosslinking density and isoelectric point, have been tuned in order to optimize gelatin degradation and drug delivery kinetics. In recent years, focus has shifted away from the use of gelatin in isolation toward the modification of gelatin with functional groups and the fabrication of material composites with embedded gelatin carriers. In this review, we highlight some of the latest work being performed in these areas and comment on trends in the field. Specifically, we discuss gelatin modifications for immune system evasion, drug stabilization, and targeted delivery, as well as gelatin composite systems based on ceramics, naturally-occurring polymers, and synthetic polymers.
dc.identifier.citationSantoro, Marco, Tatara, Alexander M. and Mikos, Antonios G.. "Gelatin carriers for drug and cell delivery in tissue engineering." <i>Journal of Controlled Release,</i> 190, (2014) Elsevier: 210-218. http://dx.doi.org/10.1016/j.jconrel.2014.04.014.
dc.identifier.doihttp://dx.doi.org/10.1016/j.jconrel.2014.04.014
dc.identifier.urihttps://hdl.handle.net/1911/81939
dc.language.isoeng
dc.publisherElsevier
dc.rightsThis is an author's peer-reviewed final manuscript, as accepted by the publisher. The published article is copyrighted by Elsevier.
dc.subject.keywordgelatin
dc.subject.keyworddrug delivery
dc.subject.keywordcell delivery
dc.subject.keywordcontrolled release
dc.subject.keywordcomposite material
dc.titleGelatin carriers for drug and cell delivery in tissue engineering
dc.typeJournal article
dc.type.dcmiText
dc.type.publicationpost-print
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
nihms586769.pdf
Size:
113.13 KB
Format:
Adobe Portable Document Format
Description:
Download
Collections
Faculty Publications
Bioengineering Publications
Chemical and Biomolecular Engineering Publications