Quantitative Analysis of High-Resolution Microendoscopic Images for Diagnosis of Esophageal Squamous Cell Carcinomaļ¾ 

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dc.citation.firstpage272en_US
dc.citation.issueNumber2en_US
dc.citation.journalTitleClinical Gastroenterology and Hepatologyen_US
dc.citation.lastpage2.79E+04en_US
dc.citation.volumeNumber13en_US
dc.contributor.authorShin, Dongsuken_US
dc.contributor.authorProtano, Marion-Annaen_US
dc.contributor.authorPolydorides, Alexandros D.en_US
dc.contributor.authorDawsey, Sanford M.en_US
dc.contributor.authorPierce, Mark C.en_US
dc.contributor.authorKim, Michelle Kangen_US
dc.contributor.authorSchwarz, Richard A.en_US
dc.contributor.authorQuang, Timothyen_US
dc.contributor.authorParikh, Neilen_US
dc.contributor.authorBhutani, Manoop S.en_US
dc.contributor.authorZhang, Fanen_US
dc.contributor.authorWang, Guiqien_US
dc.contributor.authorXue, Liyanen_US
dc.contributor.authorWang, Xueshanen_US
dc.contributor.authorXu, Hongen_US
dc.contributor.authorAnandasabapathy, Sharmilaen_US
dc.contributor.authorRichards-Kortum, Rebecca R.en_US
dc.date.accessioned2017-06-05T21:25:24Zen_US
dc.date.available2017-06-05T21:25:24Zen_US
dc.date.issued2015en_US
dc.description.abstractBackground & Aims: High-resolution microendoscopy is an optical imaging technique with the potential to improve the accuracy of endoscopic screening for esophageal squamous neoplasia. Although these microscopic images can be interpreted readily by trained personnel, quantitative image analysis software could facilitate the use of this technology in low-resource settings. In this study, we developed and evaluated quantitative image analysis criteria for the evaluation of neoplastic and non-neoplastic squamous esophageal mucosa. Methods: We performed an image analysis of 177 patients undergoing standard upper endoscopy for screening or surveillance of esophageal squamous neoplasia, using high-resolution microendoscopy, at 2 hospitals in China and at 1 hospital in the United States from May 2010 to October 2012. Biopsy specimens were collected from imaged sites (n = 375), and a consensus diagnosis was provided by 2 expert gastrointestinal pathologists and used as the standard. Results: Quantitative information from the high-resolution images was used to develop an algorithm to identify high-grade squamous dysplasia or invasive squamous cell cancer, based on histopathology findings. Optimal performance was obtained using the mean nuclear area as the basis for classification, resulting in sensitivities and specificities of 93% and 92% in the training set, 87% and 97% in the test set, and 84% and 95% in an independent validation set, respectively. Conclusions: High-resolution microendoscopy with quantitative image analysis can aid in the identification of esophageal squamous neoplasia. Use of software-based image guides may overcome issues of training and expertise in low-resource settings, allowing for widespread use of these optical biopsy technologies.en_US
dc.identifier.citationShin, Dongsuk, Protano, Marion-Anna, Polydorides, Alexandros D., et al.. "Quantitative Analysis of High-Resolution Microendoscopic Images for Diagnosis of Esophageal Squamous Cell Carcinomaļ¾ ." <i>Clinical Gastroenterology and Hepatology,</i> 13, no. 2 (2015) Elsevier: 272-279.e2. https://doi.org/10.1016/j.cgh.2014.07.030.en_US
dc.identifier.doihttps://doi.org/10.1016/j.cgh.2014.07.030en_US
dc.identifier.urihttps://hdl.handle.net/1911/94810en_US
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.rightsThis is an author's peer-reviewed final manuscript, as accepted by the publisher. The published article is copyrighted by Elsevier.en_US
dc.subject.keywordDiagnosticen_US
dc.subject.keywordEsophageal Canceren_US
dc.subject.keywordHRMEen_US
dc.subject.keywordQuantitative Diagnosisen_US
dc.titleQuantitative Analysis of High-Resolution Microendoscopic Images for Diagnosis of Esophageal Squamous Cell Carcinomaļ¾ en_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpost-printen_US
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