A New Imaging Platform for Visualizing Biological Effects of Non-Invasive Radiofrequency Electric-Field Cancer Hyperthermia

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dc.citation.firstpagee0136382en_US
dc.citation.issueNumber8en_US
dc.citation.journalTitlePLoS ONEen_US
dc.citation.volumeNumber10en_US
dc.contributor.authorCorr, Stuart J.en_US
dc.contributor.authorShamsudeen, Sabeelen_US
dc.contributor.authorVergara, Leoncio A.en_US
dc.contributor.authorHo, Jason Chak-Shingen_US
dc.contributor.authorWare, Matthew J.en_US
dc.contributor.authorKeshishian, Vazriken_US
dc.contributor.authorYokoi, Kenjien_US
dc.contributor.authorSavage, David J.en_US
dc.contributor.authorMeraz, Ismail M.en_US
dc.contributor.authorKaluarachchi, Warnaen_US
dc.contributor.authorCisneros, Brandon T.en_US
dc.contributor.authorRaoof, Mustafaen_US
dc.contributor.authorNguyen, Duy Tracen_US
dc.contributor.authorZhang, Yingchunen_US
dc.contributor.authorWilson, Lon J.en_US
dc.contributor.authorSummers, Huwen_US
dc.contributor.authorRees, Paulen_US
dc.contributor.authorCurley, Steven A.en_US
dc.contributor.authorSerda, Rita E.en_US
dc.date.accessioned2015-10-30T15:40:41Zen_US
dc.date.available2015-10-30T15:40:41Zen_US
dc.date.issued2015en_US
dc.description.abstractHerein, we present a novel imaging platform to study the biological effects of non-invasive radiofrequency (RF) electric field cancer hyperthermia. This system allows for real-time in vivointravital microscopy (IVM) imaging of radiofrequency-induced biological alterations such as changes in vessel structure and drug perfusion. Our results indicate that the IVM system is able to handle exposure to high-power electric-fields without inducing significant hardware damage or imaging artifacts. Furthermore, short durations of low-power (< 200 W) radiofrequency exposure increased transport and perfusion of fluorescent tracers into the tumors at temperatures below 41°C. Vessel deformations and blood coagulation were seen for tumor temperatures around 44°C. These results highlight the use of our integrated IVM-RF imaging platform as a powerful new tool to visualize the dynamics and interplay between radiofrequency energy and biological tissues, organs, and tumors.en_US
dc.identifier.citationCorr, Stuart J., Shamsudeen, Sabeel, Vergara, Leoncio A., et al.. "A New Imaging Platform for Visualizing Biological Effects of Non-Invasive Radiofrequency Electric-Field Cancer Hyperthermia." <i>PLoS ONE,</i> 10, no. 8 (2015) Public Library of Science: e0136382. http://dx.doi.org/10.1371/journal.pone.0136382.en_US
dc.identifier.doihttp://dx.doi.org/10.1371/journal.pone.0136382en_US
dc.identifier.urihttps://hdl.handle.net/1911/82002en_US
dc.language.isoengen_US
dc.publisherPublic Library of Scienceen_US
dc.rightsThis is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.en_US
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en_US
dc.titleA New Imaging Platform for Visualizing Biological Effects of Non-Invasive Radiofrequency Electric-Field Cancer Hyperthermiaen_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpublisher versionen_US
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