A New Imaging Platform for Visualizing Biological Effects of Non-Invasive Radiofrequency Electric-Field Cancer Hyperthermia

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dc.citation.firstpagee0136382
dc.citation.issueNumber8
dc.citation.journalTitlePLoS ONE
dc.citation.volumeNumber10
dc.contributor.authorCorr, Stuart J.
dc.contributor.authorShamsudeen, Sabeel
dc.contributor.authorVergara, Leoncio A.
dc.contributor.authorHo, Jason Chak-Shing
dc.contributor.authorWare, Matthew J.
dc.contributor.authorKeshishian, Vazrik
dc.contributor.authorYokoi, Kenji
dc.contributor.authorSavage, David J.
dc.contributor.authorMeraz, Ismail M.
dc.contributor.authorKaluarachchi, Warna
dc.contributor.authorCisneros, Brandon T.
dc.contributor.authorRaoof, Mustafa
dc.contributor.authorNguyen, Duy Trac
dc.contributor.authorZhang, Yingchun
dc.contributor.authorWilson, Lon J.
dc.contributor.authorSummers, Huw
dc.contributor.authorRees, Paul
dc.contributor.authorCurley, Steven A.
dc.contributor.authorSerda, Rita E.
dc.date.accessioned2015-10-30T15:40:41Z
dc.date.available2015-10-30T15:40:41Z
dc.date.issued2015
dc.description.abstractHerein, we present a novel imaging platform to study the biological effects of non-invasive radiofrequency (RF) electric field cancer hyperthermia. This system allows for real-time in vivointravital microscopy (IVM) imaging of radiofrequency-induced biological alterations such as changes in vessel structure and drug perfusion. Our results indicate that the IVM system is able to handle exposure to high-power electric-fields without inducing significant hardware damage or imaging artifacts. Furthermore, short durations of low-power (< 200 W) radiofrequency exposure increased transport and perfusion of fluorescent tracers into the tumors at temperatures below 41°C. Vessel deformations and blood coagulation were seen for tumor temperatures around 44°C. These results highlight the use of our integrated IVM-RF imaging platform as a powerful new tool to visualize the dynamics and interplay between radiofrequency energy and biological tissues, organs, and tumors.
dc.identifier.citationCorr, Stuart J., Shamsudeen, Sabeel, Vergara, Leoncio A., et al.. "A New Imaging Platform for Visualizing Biological Effects of Non-Invasive Radiofrequency Electric-Field Cancer Hyperthermia." <i>PLoS ONE,</i> 10, no. 8 (2015) Public Library of Science: e0136382. http://dx.doi.org/10.1371/journal.pone.0136382.
dc.identifier.doihttp://dx.doi.org/10.1371/journal.pone.0136382
dc.identifier.urihttps://hdl.handle.net/1911/82002
dc.language.isoeng
dc.publisherPublic Library of Science
dc.rightsThis is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.titleA New Imaging Platform for Visualizing Biological Effects of Non-Invasive Radiofrequency Electric-Field Cancer Hyperthermia
dc.typeJournal article
dc.type.dcmiText
dc.type.publicationpublisher version
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