Transcriptional Delay Stabilizes Bistable Gene Networks

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dc.citation.firstpage58104en_US
dc.citation.issueNumber5en_US
dc.citation.journalTitlePhysical Review Lettersen_US
dc.citation.volumeNumber111en_US
dc.contributor.authorGupta, Chinmayaen_US
dc.contributor.authorLópez, José Manuelen_US
dc.contributor.authorOtt, Williamen_US
dc.contributor.authorJosić, Krešimiren_US
dc.contributor.authorBennett, Matthew R.en_US
dc.contributor.orgInstitute of Biosciences and Bioengineeringen_US
dc.date.accessioned2014-01-21T20:19:37Zen_US
dc.date.available2014-01-21T20:19:37Zen_US
dc.date.issued2013-08en_US
dc.description.abstractTranscriptional delay can significantly impact the dynamics of gene networks. Here we examine how such delay affects bistable systems. We investigate several stochastic models of bistable gene networks and find that increasing delay dramatically increases the mean residence times near stable states. To explain this, we introduce a non-Markovian, analytically tractable reduced model. The model shows that stabilization is the consequence of an increased number of failed transitions between stable states. Each of the bistable systems that we simulate behaves in this manner.en_US
dc.identifier.citationGupta, Chinmaya, López, José Manuel, Ott, William, et al.. "Transcriptional Delay Stabilizes Bistable Gene Networks." <i>Physical Review Letters,</i> 111, no. 5 (2013) American Physical Society: 58104. http://dx.doi.org/10.1103/PhysRevLett.111.058104.en_US
dc.identifier.doihttp://dx.doi.org/10.1103/PhysRevLett.111.058104en_US
dc.identifier.urihttps://hdl.handle.net/1911/75346en_US
dc.language.isoengen_US
dc.publisherAmerican Physical Societyen_US
dc.rightsArticle is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.en_US
dc.titleTranscriptional Delay Stabilizes Bistable Gene Networksen_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpublisher versionen_US
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