Production of Short Chain Fatty Acid and its Derivatives by Genetically Engineered Escherichia coli

dc.contributor.advisorSan, Ka-Yiuen_US
dc.creatorHan, Songien_US
dc.date.accessioned2017-08-01T18:56:21Zen_US
dc.date.available2018-05-01T05:01:09Zen_US
dc.date.created2017-05en_US
dc.date.issued2017-04-20en_US
dc.date.submittedMay 2017en_US
dc.date.updated2017-08-01T18:56:21Zen_US
dc.description.abstractFatty acids are considered as valuable compounds to have a potency to be diversified into other derivatives enzymatically or chemically. Due to increasing concern regarding soaring oil price and environmental crisis, alternative ways to reduce the dependency on petroleum have received much attention, of which biocatalyst processing has been the subject of intensive research as a bio-renewable approach. Our group has generated the platform to synthesize a wide range of fatty acids with tailored chain length and functional groups by using E. coli as a host. Considerable efforts have been made, and the corresponding improvement in the production of fatty acids has been achieved so far. Since this progress is limited to long chain length fatty acid in most cases, we have made an attempt to customize the chain length shorter than C12 by exploiting some strategies used in metabolic engineering. As a result of adopting many metabolic engineering strategies, we have found a significant improvement in the production of short chain fatty acids.en_US
dc.embargo.terms2018-05-01en_US
dc.format.mimetypeapplication/pdfen_US
dc.identifier.citationHan, Songi. "Production of Short Chain Fatty Acid and its Derivatives by Genetically Engineered Escherichia coli." (2017) Diss., Rice University. <a href="https://hdl.handle.net/1911/96127">https://hdl.handle.net/1911/96127</a>.en_US
dc.identifier.urihttps://hdl.handle.net/1911/96127en_US
dc.language.isoengen_US
dc.rightsCopyright is held by the author, unless otherwise indicated. Permission to reuse, publish, or reproduce the work beyond the bounds of fair use or other exemptions to copyright law must be obtained from the copyright holder.en_US
dc.subjectShort chain fatty aciden_US
dc.titleProduction of Short Chain Fatty Acid and its Derivatives by Genetically Engineered Escherichia colien_US
dc.typeThesisen_US
dc.type.materialTexten_US
thesis.degree.departmentBioengineeringen_US
thesis.degree.disciplineEngineeringen_US
thesis.degree.grantorRice Universityen_US
thesis.degree.levelDoctoralen_US
thesis.degree.nameDoctor of Philosophyen_US
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