Noncovalent Assembly of Targeted Carbon Nanovectors Enables Synergistic Drug and Radiation Cancer Therapyﾠin Vivo

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dc.citation.firstpage2497en_US
dc.citation.issueNumber3en_US
dc.citation.journalTitleACS Nanoen_US
dc.citation.lastpage2505en_US
dc.citation.volumeNumber6en_US
dc.contributor.authorSano, Daisukeen_US
dc.contributor.authorBerlin, Jacob M.en_US
dc.contributor.authorPham, Tam T.en_US
dc.contributor.authorMarcano, Daniela C.en_US
dc.contributor.authorValdecanas, David R.en_US
dc.contributor.authorZhou, Geen_US
dc.contributor.authorMilas, Lukaen_US
dc.contributor.authorMyers, Jeffrey N.en_US
dc.contributor.authorTour, James M.en_US
dc.contributor.orgSmalley Institute for Nanoscale Science and Technologyen_US
dc.date.accessioned2016-06-08T16:16:52Z
dc.date.available2016-06-08T16:16:52Z
dc.date.issued2012en_US
dc.description.abstractCurrent chemotherapeutics are characterized by efficient tumor cell-killing and severe side effects mostly derived from off-target toxicity. Hence targeted delivery of these drugs to tumor cells is actively sought. In anﾠin vitroﾠsystem, we previously demonstrated that targeted drug delivery to cancer cells overexpressing epidermal growth factor receptor (EGFR+) can be achieved by poly(ethylene glycol)-functionalized carbon nanovectors simply mixed with a drug, paclitaxel, and an antibody that binds to the epidermal growth factor receptor, cetuximab. This construct is unusual in that all three components are assembled through noncovalent interactions. Here we show that this same construct is effectiveﾠin vivo, enhancing radiotherapy of EGFR+ tumors. This targeted nanovector system has the potential to be a new therapy for head and neck squamous cell carcinomas, deserving of further preclinical development.en_US
dc.identifier.citationSano, Daisuke, Berlin, Jacob M., Pham, Tam T., et al.. "Noncovalent Assembly of Targeted Carbon Nanovectors Enables Synergistic Drug and Radiation Cancer Therapyﾠin Vivo." <i>ACS Nano,</i> 6, no. 3 (2012) American Chemical Society: 2497-2505. http://dx.doi.org/10.1021/nn204885f.
dc.identifier.doihttp://dx.doi.org/10.1021/nn204885fen_US
dc.identifier.urihttps://hdl.handle.net/1911/90465
dc.language.isoengen_US
dc.publisherAmerican Chemical Society
dc.rightsThis is an author's peer-reviewed final manuscript, as accepted by the publisher. The published article is copyrighted by the American Chemical Society.en_US
dc.subject.keywordtargeted drug deliveryen_US
dc.subject.keywordcanceren_US
dc.subject.keywordnanovectorsen_US
dc.subject.keywordhydrophilic carbon clustersen_US
dc.subject.keywordCetuximaben_US
dc.subject.keywordEGFR+en_US
dc.titleNoncovalent Assembly of Targeted Carbon Nanovectors Enables Synergistic Drug and Radiation Cancer Therapyﾠin Vivoen_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpost-printen_US
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