Three-dimensional printing of multilayered tissue engineering scaffolds

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dc.citation.firstpage861en_US
dc.citation.issueNumber8en_US
dc.citation.journalTitleMaterials Todayen_US
dc.citation.lastpage874en_US
dc.citation.volumeNumber21en_US
dc.contributor.authorBittner, Sean M.en_US
dc.contributor.authorGuo, Jason L.en_US
dc.contributor.authorMelchiorri, Anthonyen_US
dc.contributor.authorMikos, Antonios G.en_US
dc.contributor.orgBioengineeringen_US
dc.date.accessioned2019-11-05T17:30:06Zen_US
dc.date.available2019-11-05T17:30:06Zen_US
dc.date.issued2018en_US
dc.description.abstractThe field of tissue engineering has produced new therapies for the repair of damaged tissues and organs, utilizing biomimetic scaffolds that mirror the mechanical and biological properties of host tissue. The emergence of three-dimensional printing (3DP) technologies has enabled the fabrication of highly complex scaffolds that offer a more accurate replication of native tissue properties and architecture than previously possible. Of strong interest to tissue engineers is the construction of multilayered scaffolds that target distinct regions of complex tissues. Musculoskeletal and dental tissues in particular, such as the osteochondral unit and periodontal complex, are composed of multiple interfacing tissue types, and thus benefit from the usage of multilayered scaffold fabrication. Traditional 3DP technologies such as extrusion printing and selective laser sintering have been used for the construction of scaffolds with gradient architectures and mixed material compositions. Additionally, emerging bioprinting strategies have been used for the direct printing and spatial patterning of cells and chemical factors, capturing the complex organization found in the body. To better replicate the varied and gradated properties of larger tissues, researchers have created scaffolds composed of multiple materials spanning natural polymers, synthetic polymers, and ceramics. By utilizing high-precision 3DP techniques and judicious material selection, scaffolds can thus be designed to address the regeneration of previously challenging musculoskeletal, dental, and other heterogeneous target tissues. These multilayered 3DP strategies show great promise in the future of tissue engineering.en_US
dc.identifier.citationBittner, Sean M., Guo, Jason L., Melchiorri, Anthony, et al.. "Three-dimensional printing of multilayered tissue engineering scaffolds." <i>Materials Today,</i> 21, no. 8 (2018) Elsevier: 861-874. https://doi.org/10.1016/j.mattod.2018.02.006.en_US
dc.identifier.digitalnihms953254en_US
dc.identifier.doihttps://doi.org/10.1016/j.mattod.2018.02.006en_US
dc.identifier.urihttps://hdl.handle.net/1911/107603en_US
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.rightsThis is an author's peer-reviewed final manuscript, as accepted by the publisher. The published article is copyrighted by Elsevier.en_US
dc.titleThree-dimensional printing of multilayered tissue engineering scaffoldsen_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpost-printen_US
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