A longitudinal cohort study of malaria exposure and changing serostatus in a malaria endemic area of rural Tanzania

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dc.contributor.authorSimmons, Ryan A.en_US
dc.contributor.authorMboera, Leonarden_US
dc.contributor.authorMiranda, Marie L.en_US
dc.contributor.authorMorris, Alisonen_US
dc.contributor.authorStresman, Gillianen_US
dc.contributor.authorTurner, Elizabeth L.en_US
dc.contributor.authorKramer, Randallen_US
dc.contributor.authorDrakeley, Chrisen_US
dc.contributor.authorO’Meara, Wendy P.en_US
dc.date.accessioned2017-08-21T07:23:10Zen_US
dc.date.available2017-08-21T07:23:10Zen_US
dc.date.issued8/2/2017en_US
dc.date.updated2017-08-21T07:23:09Zen_US
dc.description.abstractAbstract Background Measurements of anti-malarial antibodies are increasingly used as a proxy of transmission intensity. Most serological surveys are based on the use of cross-sectional data that, when age-stratified, approximates historical patterns of transmission within a population. Comparatively few studies leverage longitudinal data to explicitly relate individual infection events with subsequent antibody responses. Methods The occurrence of seroconversion and seroreversion events for two Plasmodium falciparum asexual stage antigens (MSP-1 and AMA-1) was examined using three annual measurements of 691 individuals from a cohort of individuals in a malaria-endemic area of rural east-central Tanzania. Mixed-effect logistic regression models were employed to determine factors associated with changes in serostatus over time. Results While the expected population-level relationship between seroprevalence and disease incidence was observed, on an individual level the relationship between individual infections and the antibody response was complex. MSP-1 antibody responses were more dynamic in response to the occurrence and resolution of infection events than AMA-1, while the latter was more correlated with consecutive infections. The MSP-1 antibody response to an observed infection seemed to decay faster over time than the corresponding AMA-1 response. Surprisingly, there was no evidence of an age effect on the occurrence of a conversion or reversion event. Conclusions While the population-level results concur with previously published sero-epidemiological surveys, the individual-level results highlight the more complex relationship between detected infections and antibody dynamics than can be analysed using cross-sectional data. The longitudinal analysis of serological data may provide a powerful tool for teasing apart the complex relationship between infection events and the corresponding immune response, thereby improving the ability to rapidly assess the success or failure of malaria control programmes.en_US
dc.identifier.citationSimmons, Ryan A., Mboera, Leonard, Miranda, Marie L., et al.. "A longitudinal cohort study of malaria exposure and changing serostatus in a malaria endemic area of rural Tanzania." (2017) BioMed Central: http://dx.doi.org/10.1186/s12936-017-1945-2.en_US
dc.identifier.doihttp://dx.doi.org/10.1186/s12936-017-1945-2en_US
dc.identifier.urihttps://hdl.handle.net/1911/97361en_US
dc.language.isoengen_US
dc.publisherBioMed Centralen_US
dc.rights.holderThe Author(s)en_US
dc.titleA longitudinal cohort study of malaria exposure and changing serostatus in a malaria endemic area of rural Tanzaniaen_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpublisher versionen_US
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