Rhodium(II) Proximity-Labeling Identifies a Novel Target Site on STAT3 for Inhibitors with Potent Anti-Leukemia Activity

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dc.citation.firstpage13085
dc.citation.issueNumber44
dc.citation.journalTitleAngewandte Chemie International Edition
dc.citation.lastpage13089
dc.citation.volumeNumber54
dc.contributor.authorMinus, Matthew B.
dc.contributor.authorLiu, Wei
dc.contributor.authorVohidov, Farrukh
dc.contributor.authorKasembeli, Moses M.
dc.contributor.authorLong, Xin
dc.contributor.authorKrueger, Michael
dc.contributor.authorStevens, Alexandra
dc.contributor.authorKolosov, Mikhail I.
dc.contributor.authorTweardy, David J.
dc.contributor.authorSison, Edward Allen R.
dc.contributor.authorRedell, Michele S.
dc.contributor.authorBall, Zachary T.
dc.date.accessioned2017-05-12T17:10:13Z
dc.date.available2017-05-12T17:10:13Z
dc.date.issued2015
dc.description.abstractNearly 40 % of children with acute myeloid leukemia (AML) suffer relapse arising from chemoresistance, often involving upregulation of the oncoprotein STAT3 (signal transducer and activator of transcription 3). Herein, rhodium(II)-catalyzed, proximity-driven modification identifies the STAT3 coiled-coil domain (CCD) as a novel ligand-binding site, and we describe a new naphthalene sulfonamide inhibitor that targets the CCD, blocks STAT3 function, and halts its disease-promoting effects in vitro, in tumor growth models, and in a leukemia mouse model, validating this new therapeutic target for resistant AML.
dc.identifier.citationMinus, Matthew B., Liu, Wei, Vohidov, Farrukh, et al.. "Rhodium(II) Proximity-Labeling Identifies a Novel Target Site on STAT3 for Inhibitors with Potent Anti-Leukemia Activity." <i>Angewandte Chemie International Edition,</i> 54, no. 44 (2015) Wiley: 13085-13089. http://dx.doi.org/10.1002/anie.201506889.
dc.identifier.doihttp://dx.doi.org/10.1002/anie.201506889
dc.identifier.urihttps://hdl.handle.net/1911/94238
dc.language.isoeng
dc.publisherWiley
dc.rightsThis is an author's peer-reviewed final manuscript, as accepted by the publisher. The published article is copyrighted by Wiley.
dc.titleRhodium(II) Proximity-Labeling Identifies a Novel Target Site on STAT3 for Inhibitors with Potent Anti-Leukemia Activity
dc.typeJournal article
dc.type.dcmiText
dc.type.publicationpost-print
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