Rhodium(II) Proximity-Labeling Identifies a Novel Target Site on STAT3 for Inhibitors with Potent Anti-Leukemia Activity

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dc.citation.firstpage13085en_US
dc.citation.issueNumber44en_US
dc.citation.journalTitleAngewandte Chemie International Editionen_US
dc.citation.lastpage13089en_US
dc.citation.volumeNumber54en_US
dc.contributor.authorMinus, Matthew B.en_US
dc.contributor.authorLiu, Weien_US
dc.contributor.authorVohidov, Farrukhen_US
dc.contributor.authorKasembeli, Moses M.en_US
dc.contributor.authorLong, Xinen_US
dc.contributor.authorKrueger, Michaelen_US
dc.contributor.authorStevens, Alexandraen_US
dc.contributor.authorKolosov, Mikhail I.en_US
dc.contributor.authorTweardy, David J.en_US
dc.contributor.authorSison, Edward Allen R.en_US
dc.contributor.authorRedell, Michele S.en_US
dc.contributor.authorBall, Zachary T.en_US
dc.date.accessioned2017-05-12T17:10:13Zen_US
dc.date.available2017-05-12T17:10:13Zen_US
dc.date.issued2015en_US
dc.description.abstractNearly 40 % of children with acute myeloid leukemia (AML) suffer relapse arising from chemoresistance, often involving upregulation of the oncoprotein STAT3 (signal transducer and activator of transcription 3). Herein, rhodium(II)-catalyzed, proximity-driven modification identifies the STAT3 coiled-coil domain (CCD) as a novel ligand-binding site, and we describe a new naphthalene sulfonamide inhibitor that targets the CCD, blocks STAT3 function, and halts its disease-promoting effects in vitro, in tumor growth models, and in a leukemia mouse model, validating this new therapeutic target for resistant AML.en_US
dc.identifier.citationMinus, Matthew B., Liu, Wei, Vohidov, Farrukh, et al.. "Rhodium(II) Proximity-Labeling Identifies a Novel Target Site on STAT3 for Inhibitors with Potent Anti-Leukemia Activity." <i>Angewandte Chemie International Edition,</i> 54, no. 44 (2015) Wiley: 13085-13089. http://dx.doi.org/10.1002/anie.201506889.en_US
dc.identifier.doihttp://dx.doi.org/10.1002/anie.201506889en_US
dc.identifier.urihttps://hdl.handle.net/1911/94238en_US
dc.language.isoengen_US
dc.publisherWileyen_US
dc.rightsThis is an author's peer-reviewed final manuscript, as accepted by the publisher. The published article is copyrighted by Wiley.en_US
dc.titleRhodium(II) Proximity-Labeling Identifies a Novel Target Site on STAT3 for Inhibitors with Potent Anti-Leukemia Activityen_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpost-printen_US
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