A high-resolution microendoscope system includes a light source, a fiber optic bundle configured to transmit light from the light source to a sample, a disc configured to receive light returned from the sample, the disc having spaced apart segments, the spaced-apart segments being at least one of openings and transparent portions, a first camera configured to capture a first image based at least in part on light passing through the disc, and a second camera configured to capture a second image based at least in part on light reflected from the disc.