Influence of musculoskeletal model parameter values on prediction of accurate knee contact forces during walking

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dc.citation.firstpage35en_US
dc.citation.journalTitleMedical Engineering & Physicsen_US
dc.citation.lastpage47en_US
dc.citation.volumeNumber85en_US
dc.contributor.authorSerrancolí, Gilen_US
dc.contributor.authorKinney, Allison L.en_US
dc.contributor.authorFregly, Benjamin J.en_US
dc.date.accessioned2020-10-16T18:44:39Zen_US
dc.date.available2020-10-16T18:44:39Zen_US
dc.date.issued2020en_US
dc.description.abstractTreatment design for musculoskeletal disorders using in silico patient-specific dynamic simulations is becoming a clinical possibility. However, these simulations are sensitive to model parameter values that are difficult to measure experimentally, and the influence of uncertainties in these parameter values on the accuracy of estimated knee contact forces remains unknown. This study evaluates which musculoskeletal model parameters have the greatest influence on estimating accurate knee contact forces during walking. We performed the evaluation using a two-level optimization algorithm where musculoskeletal model parameter values were adjusted in the outer level and muscle activations were estimated in the inner level. We tested the algorithm with different sets of design variables (combinations of optimal muscle fiber lengths, tendon slack lengths, and muscle moment arm offsets) resulting in nine different optimization problems. The most accurate lateral knee contact force predictions were obtained when tendon slack lengths and moment arm offsets were adjusted simultaneously, and the most accurate medial knee contact force estimations were obtained when all three types of parameters were adjusted together. Inclusion of moment arm offsets as design variables was more important than including either tendon slack lengths or optimal muscle fiber lengths alone to obtain accurate medial and lateral knee contact force predictions. These results provide guidance on which musculoskeletal model parameter values should be calibrated when seeking to predict in vivo knee contact forces accurately.en_US
dc.identifier.citationSerrancolí, Gil, Kinney, Allison L. and Fregly, Benjamin J.. "Influence of musculoskeletal model parameter values on prediction of accurate knee contact forces during walking." <i>Medical Engineering & Physics,</i> 85, (2020) Elsevier: 35-47. https://doi.org/10.1016/j.medengphy.2020.09.004.en_US
dc.identifier.doihttps://doi.org/10.1016/j.medengphy.2020.09.004en_US
dc.identifier.urihttps://hdl.handle.net/1911/109426en_US
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.rightsThis is an author's peer-reviewed final manuscript, as accepted by the publisher. The published article is copyrighted by Elsevier.en_US
dc.subject.keywordMuscle-tendon model parametersen_US
dc.subject.keywordMuscle force estimationen_US
dc.subject.keywordKnee contact force predictionen_US
dc.subject.keywordMusculoskeletal modelingen_US
dc.titleInfluence of musculoskeletal model parameter values on prediction of accurate knee contact forces during walkingen_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpost-printen_US
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