Synthetic studies on ecteinascidin 743

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dc.contributor.advisorFukuyama, Tohru
dc.creatorJow, Chung-Kuang
dc.date.accessioned2009-06-04T00:22:13Z
dc.date.available2009-06-04T00:22:13Z
dc.date.issued1995
dc.description.abstractSynthetic studies on ecteinascidin 743 (b), an antitumor antibiotic, are described. The key reactions include: (1) an acylimmium ion-mediated stereoselective construction of the optically pure diazobicyclo (3.3.1) nonane nucleus 6, (2) a stereocontrolled Pictet-Spengler cyclization for the formation of tetrahydroisoquinoline 2, and (3) the attempted benzylic oxidation of the pentacyclic phenol 22.(DIAGRAM, TABLE OR GRAPHIC OMITTED...PLEASE SEE DAI)
dc.format.extent176 p.en_US
dc.format.mimetypeapplication/pdf
dc.identifier.callnoTHESIS CHEM. 1995 JOW
dc.identifier.citationJow, Chung-Kuang. "Synthetic studies on ecteinascidin 743." (1995) Diss., Rice University. <a href="https://hdl.handle.net/1911/16835">https://hdl.handle.net/1911/16835</a>.
dc.identifier.urihttps://hdl.handle.net/1911/16835
dc.language.isoeng
dc.rightsCopyright is held by the author, unless otherwise indicated. Permission to reuse, publish, or reproduce the work beyond the bounds of fair use or other exemptions to copyright law must be obtained from the copyright holder.
dc.subjectOrganic chemistry
dc.titleSynthetic studies on ecteinascidin 743
dc.typeThesis
dc.type.materialText
thesis.degree.departmentChemistry
thesis.degree.disciplineNatural Sciences
thesis.degree.grantorRice University
thesis.degree.levelDoctoral
thesis.degree.nameDoctor of Philosophy
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