Synthetic studies on ecteinascidin 743
Date
1995
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Abstract
Synthetic studies on ecteinascidin 743 (b), an antitumor antibiotic, are described. The key reactions include: (1) an acylimmium ion-mediated stereoselective construction of the optically pure diazobicyclo (3.3.1) nonane nucleus 6, (2) a stereocontrolled Pictet-Spengler cyclization for the formation of tetrahydroisoquinoline 2, and (3) the attempted benzylic oxidation of the pentacyclic phenol 22.(DIAGRAM, TABLE OR GRAPHIC OMITTED...PLEASE SEE DAI)
Description
Advisor
Degree
Doctor of Philosophy
Type
Thesis
Keywords
Organic chemistry
Citation
Jow, Chung-Kuang. "Synthetic studies on ecteinascidin 743." (1995) Diss., Rice University. https://hdl.handle.net/1911/16835.
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