A model of the aortic baroreceptor in rat

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dc.contributor.advisorClark, John W., Jr.en_US
dc.creatorAlfrey, Karen D.en_US
dc.date.accessioned2009-06-04T08:13:17Zen_US
dc.date.available2009-06-04T08:13:17Zen_US
dc.date.issued1997en_US
dc.description.abstractThe baroreceptor, a stretch-sensitive neuron, senses static and dynamic arterial blood pressure and responds by producing a frequency-modulated train of action potentials. The size and anatomy of baroreceptor nerve endings precludes direct experimental study of the details of baroreceptor behavior; however, studies of output firing frequency in response to arterial pressure changes reveal a highly nonlinear input-output characteristic. While many models of the baroreceptor have been developed, most of these models have failed to provide a comprehensive view of the mechanisms under-lying baroreceptor function. We present a new baroreceptor model which provides a physiologically-based, comprehensive description of all aspects of the system. This model combines a mechanical model of the arterial wall with Hodgkin-Huxley-type models of the transducer and encoder sections of the neuron. The complete model not only mimics a wide range of experimental results, it also provides a means of making predictions about baroreceptor behavior and of examining the mechanisms underlying baroreceptor function.en_US
dc.format.extent86 p.en_US
dc.format.mimetypeapplication/pdfen_US
dc.identifier.callnoTHESIS E.E. 1997 ALFREYen_US
dc.identifier.citationAlfrey, Karen D.. "A model of the aortic baroreceptor in rat." (1997) Master’s Thesis, Rice University. <a href="https://hdl.handle.net/1911/17059">https://hdl.handle.net/1911/17059</a>.en_US
dc.identifier.urihttps://hdl.handle.net/1911/17059en_US
dc.language.isoengen_US
dc.rightsCopyright is held by the author, unless otherwise indicated. Permission to reuse, publish, or reproduce the work beyond the bounds of fair use or other exemptions to copyright law must be obtained from the copyright holder.en_US
dc.subjectPhysiologyen_US
dc.subjectBiomedical engineeringen_US
dc.subjectElectronicsen_US
dc.subjectElectrical engineeringen_US
dc.titleA model of the aortic baroreceptor in raten_US
dc.typeThesisen_US
dc.type.materialTexten_US
thesis.degree.departmentElectrical Engineeringen_US
thesis.degree.disciplineEngineeringen_US
thesis.degree.grantorRice Universityen_US
thesis.degree.levelMastersen_US
thesis.degree.nameMaster of Scienceen_US
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