Externally modulated theranostic nanoparticles

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dc.citation.firstpage292en_US
dc.citation.issueNumber4en_US
dc.citation.journalTitleTranslational Cancer Researchen_US
dc.citation.lastpage308en_US
dc.citation.volumeNumber2en_US
dc.contributor.authorUrban, Cordulaen_US
dc.contributor.authorUrban, Alexander S.en_US
dc.contributor.authorCharron, Heatheren_US
dc.contributor.authorJoshi, Amiten_US
dc.date.accessioned2014-10-07T21:52:28Zen_US
dc.date.available2014-10-07T21:52:28Zen_US
dc.date.issued2013en_US
dc.description.abstractExternally modulated nanoparticles comprise a rapidly advancing class of cancer nanotherapeutics, which combine the favorable tumor accumulation of nanoparticles, with external spatio-temporal control on therapy delivery via optical, magnetic, or ultrasound modalities. The local control on therapy enables higher tumor treatment efficacy, while simultaneously reducing off-target effects. The nanoparticle interactions with external fields have an additional advantage of frequently generating an imaging signal, and thus such agents provide theranostic (both diagnostic and therapeutic) capabilities. In this review, we classify the emerging externally modulated theranostic nanoparticles according to the mode of external control and describe the physiochemical mechanisms underlying the external control of therapy, and illustrate the major embodiments of nanoparticles in each class with proven biological efficacy: (I) electromagnetic radiation in visible and near infrared range is being exploited for gold based and carbon nanostructures with tunable surface plasmon resonance (SPR) for imaging and photothermal therapy (PTT) of cancer, photochemistry based manipulations are employed for light sensitive liposomes and porphyrin based nanoparticles; (II) Magnetic field based manipulations are being developed for iron-oxide based nanostructures for magnetic resonance imaging (MRI) and magnetothermal therapy; (III) ultrasound based methods are primarily being employed to increase delivery of conventional drugs and nanotherapeutics to tumor sites.en_US
dc.identifier.citationUrban, Cordula, Urban, Alexander S., Charron, Heather, et al.. "Externally modulated theranostic nanoparticles." <i>Translational Cancer Research,</i> 2, no. 4 (2013) Pioneer Bioscience Publishing Company: 292-308. http://dx.doi.org/10.3978/j.issn.2218-676X.2013.08.05.en_US
dc.identifier.doihttp://dx.doi.org/10.3978/j.issn.2218-676X.2013.08.05en_US
dc.identifier.urihttps://hdl.handle.net/1911/77434en_US
dc.language.isoengen_US
dc.publisherPioneer Bioscience Publishing Companyen_US
dc.rightsArticle is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.en_US
dc.subject.keywordcancer nanotechnologyen_US
dc.subject.keywordtheranosticsen_US
dc.subject.keywordhyperthermiaen_US
dc.subject.keywordNIR therapyen_US
dc.subject.keywordgold nanoparticles (AuNPs)en_US
dc.titleExternally modulated theranostic nanoparticlesen_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpublisher versionen_US
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