Structure and function of axo-axonic inhibition

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dc.citation.articleNumbere73783
dc.citation.journalTitleeLife
dc.citation.volumeNumber10
dc.contributor.authorSchneider-Mizell, Casey M.
dc.contributor.authorBodor, Agnes L.
dc.contributor.authorCollman, Forrest
dc.contributor.authorBrittain, Derrick
dc.contributor.authorBleckert, Adam
dc.contributor.authorDorkenwald, Sven
dc.contributor.authorTurner, Nicholas L.
dc.contributor.authorMacrina, Thomas
dc.contributor.authorLee, Kisuk
dc.contributor.authorLu, Ran
dc.contributor.authorWu, Jingpeng
dc.contributor.authorZhuang, Jun
dc.contributor.authorNandi, Anirban
dc.contributor.authorHu, Brian
dc.contributor.authorBuchanan, JoAnn
dc.contributor.authorTakeno, Marc M.
dc.contributor.authorTorres, Russel
dc.contributor.authorMahalingam, Gayathri
dc.contributor.authorBumbarger, Daniel J.
dc.contributor.authorLi, Yang
dc.contributor.authorChartrand, Thomas
dc.contributor.authorKemnitz, Nico
dc.contributor.authorSilversmith, William M.
dc.contributor.authorIh, Dodam
dc.contributor.authorZung, Jonathan
dc.contributor.authorZlateski, Aleksandar
dc.contributor.authorTartavull, Ignacio
dc.contributor.authorPopovych, Sergiy
dc.contributor.authorWong, William
dc.contributor.authorCastro, Manuel
dc.contributor.authorJordan, Chris S.
dc.contributor.authorFroudarakis, Emmanouil
dc.contributor.authorBecker, Lynne
dc.contributor.authorSuckow, Shelby
dc.contributor.authorReimer, Jacob
dc.contributor.authorTolias, Andreas S.
dc.contributor.authorAnastassiou, Costas A.
dc.contributor.authorSeung, H. Sebastian
dc.contributor.authorReid, R. Clay
dc.contributor.authorCosta, Nuno Maçarico da
dc.date.accessioned2022-01-21T16:24:04Z
dc.date.available2022-01-21T16:24:04Z
dc.date.issued2021
dc.description.abstractInhibitory neurons in mammalian cortex exhibit diverse physiological, morphological, molecular, and connectivity signatures. While considerable work has measured the average connectivity of several interneuron classes, there remains a fundamental lack of understanding of the connectivity distribution of distinct inhibitory cell types with synaptic resolution, how it relates to properties of target cells, and how it affects function. Here, we used large-scale electron microscopy and functional imaging to address these questions for chandelier cells in layer 2/3 of the mouse visual cortex. With dense reconstructions from electron microscopy, we mapped the complete chandelier input onto 153 pyramidal neurons. We found that synapse number is highly variable across the population and is correlated with several structural features of the target neuron. This variability in the number of axo-axonic ChC synapses is higher than the variability seen in perisomatic inhibition. Biophysical simulations show that the observed pattern of axo-axonic inhibition is particularly effective in controlling excitatory output when excitation and inhibition are co-active. Finally, we measured chandelier cell activity in awake animals using a cell-type-specific calcium imaging approach and saw highly correlated activity across chandelier cells. In the same experiments, in vivo chandelier population activity correlated with pupil dilation, a proxy for arousal. Together, these results suggest that chandelier cells provide a circuit-wide signal whose strength is adjusted relative to the properties of target neurons.
dc.identifier.citationSchneider-Mizell, Casey M., Bodor, Agnes L., Collman, Forrest, et al.. "Structure and function of axo-axonic inhibition." <i>eLife,</i> 10, (2021) eLife Sciences Publications Ltd: https://doi.org/10.7554/eLife.73783.
dc.identifier.digitalelife-73783-v2
dc.identifier.doihttps://doi.org/10.7554/eLife.73783
dc.identifier.urihttps://hdl.handle.net/1911/111936
dc.language.isoeng
dc.publishereLife Sciences Publications Ltd
dc.rightsThis article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.titleStructure and function of axo-axonic inhibition
dc.typeJournal article
dc.type.dcmiText
dc.type.publicationpublisher version
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