Structure and function of axo-axonic inhibition

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dc.citation.articleNumbere73783en_US
dc.citation.journalTitleeLifeen_US
dc.citation.volumeNumber10en_US
dc.contributor.authorSchneider-Mizell, Casey M.en_US
dc.contributor.authorBodor, Agnes L.en_US
dc.contributor.authorCollman, Forresten_US
dc.contributor.authorBrittain, Derricken_US
dc.contributor.authorBleckert, Adamen_US
dc.contributor.authorDorkenwald, Svenen_US
dc.contributor.authorTurner, Nicholas L.en_US
dc.contributor.authorMacrina, Thomasen_US
dc.contributor.authorLee, Kisuken_US
dc.contributor.authorLu, Ranen_US
dc.contributor.authorWu, Jingpengen_US
dc.contributor.authorZhuang, Junen_US
dc.contributor.authorNandi, Anirbanen_US
dc.contributor.authorHu, Brianen_US
dc.contributor.authorBuchanan, JoAnnen_US
dc.contributor.authorTakeno, Marc M.en_US
dc.contributor.authorTorres, Russelen_US
dc.contributor.authorMahalingam, Gayathrien_US
dc.contributor.authorBumbarger, Daniel J.en_US
dc.contributor.authorLi, Yangen_US
dc.contributor.authorChartrand, Thomasen_US
dc.contributor.authorKemnitz, Nicoen_US
dc.contributor.authorSilversmith, William M.en_US
dc.contributor.authorIh, Dodamen_US
dc.contributor.authorZung, Jonathanen_US
dc.contributor.authorZlateski, Aleksandaren_US
dc.contributor.authorTartavull, Ignacioen_US
dc.contributor.authorPopovych, Sergiyen_US
dc.contributor.authorWong, Williamen_US
dc.contributor.authorCastro, Manuelen_US
dc.contributor.authorJordan, Chris S.en_US
dc.contributor.authorFroudarakis, Emmanouilen_US
dc.contributor.authorBecker, Lynneen_US
dc.contributor.authorSuckow, Shelbyen_US
dc.contributor.authorReimer, Jacoben_US
dc.contributor.authorTolias, Andreas S.en_US
dc.contributor.authorAnastassiou, Costas A.en_US
dc.contributor.authorSeung, H. Sebastianen_US
dc.contributor.authorReid, R. Clayen_US
dc.contributor.authorCosta, Nuno Maçarico daen_US
dc.date.accessioned2022-01-21T16:24:04Zen_US
dc.date.available2022-01-21T16:24:04Zen_US
dc.date.issued2021en_US
dc.description.abstractInhibitory neurons in mammalian cortex exhibit diverse physiological, morphological, molecular, and connectivity signatures. While considerable work has measured the average connectivity of several interneuron classes, there remains a fundamental lack of understanding of the connectivity distribution of distinct inhibitory cell types with synaptic resolution, how it relates to properties of target cells, and how it affects function. Here, we used large-scale electron microscopy and functional imaging to address these questions for chandelier cells in layer 2/3 of the mouse visual cortex. With dense reconstructions from electron microscopy, we mapped the complete chandelier input onto 153 pyramidal neurons. We found that synapse number is highly variable across the population and is correlated with several structural features of the target neuron. This variability in the number of axo-axonic ChC synapses is higher than the variability seen in perisomatic inhibition. Biophysical simulations show that the observed pattern of axo-axonic inhibition is particularly effective in controlling excitatory output when excitation and inhibition are co-active. Finally, we measured chandelier cell activity in awake animals using a cell-type-specific calcium imaging approach and saw highly correlated activity across chandelier cells. In the same experiments, in vivo chandelier population activity correlated with pupil dilation, a proxy for arousal. Together, these results suggest that chandelier cells provide a circuit-wide signal whose strength is adjusted relative to the properties of target neurons.en_US
dc.identifier.citationSchneider-Mizell, Casey M., Bodor, Agnes L., Collman, Forrest, et al.. "Structure and function of axo-axonic inhibition." <i>eLife,</i> 10, (2021) eLife Sciences Publications Ltd: https://doi.org/10.7554/eLife.73783.en_US
dc.identifier.digitalelife-73783-v2en_US
dc.identifier.doihttps://doi.org/10.7554/eLife.73783en_US
dc.identifier.urihttps://hdl.handle.net/1911/111936en_US
dc.language.isoengen_US
dc.publishereLife Sciences Publications Ltden_US
dc.rightsThis article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.en_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en_US
dc.titleStructure and function of axo-axonic inhibitionen_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpublisher versionen_US
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