Electrostatic polarization fields trigger glioblastoma stem cell differentiation

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dc.citation.firstpage95
dc.citation.journalTitleNanoscale Horizons
dc.citation.lastpage107
dc.citation.volumeNumber8
dc.contributor.authorCabada, Tamara Fernandez
dc.contributor.authorRuben, Massimo
dc.contributor.authorMerhie, Amira El
dc.contributor.authorZaccaria, Remo Proietti
dc.contributor.authorAlabastri, Alessandro
dc.contributor.authorPetrini, Enrica Maria
dc.contributor.authorBarberis, Andrea
dc.contributor.authorSalerno, Marco
dc.contributor.authorCrepaldi, Marco
dc.contributor.authorDavis, Alexander
dc.contributor.authorCeseracciu, Luca
dc.contributor.authorCatelani, Tiziano
dc.contributor.authorAthanassiou, Athanassia
dc.contributor.authorPellegrino, Teresa
dc.contributor.authorCingolani, Roberto
dc.contributor.authorPapadopoulou, Evie L.
dc.date.accessioned2023-01-27T14:47:24Z
dc.date.available2023-01-27T14:47:24Z
dc.date.issued2022
dc.description.abstractOver the last few years it has been understood that the interface between living cells and the underlying materials can be a powerful tool to manipulate cell functions. In this study, we explore the hypothesis that the electrical cell/material interface can regulate the differentiation of cancer stem-like cells (CSCs). Electrospun polymer fibres, either polyamide 66 or poly(lactic acid), with embedded graphene nanoplatelets (GnPs), have been fabricated as CSC scaffolds, providing both the 3D microenvironment and a suitable electrical environment favorable for CSCs adhesion, growth and differentiation. We have investigated the impact of these scaffolds on the morphological, immunostaining and electrophysiological properties of CSCs extracted from human glioblastoma multiform (GBM) tumor cell line. Our data provide evidence in favor of the ability of GnP-incorporating scaffolds to promote CSC differentiation to the glial phenotype. Numerical simulations support the hypothesis that the electrical interface promotes the hyperpolarization of the cell membrane potential, thus triggering the CSC differentiation. We propose that the electrical cell/material interface can regulate endogenous bioelectrical cues, through the membrane potential manipulation, resulting in the differentiation of CSCs. Material-induced differentiation of stem cells and particularly of CSCs, can open new horizons in tissue engineering and new approaches to cancer treatment, especially GBM.
dc.identifier.citationCabada, Tamara Fernandez, Ruben, Massimo, Merhie, Amira El, et al.. "Electrostatic polarization fields trigger glioblastoma stem cell differentiation." <i>Nanoscale Horizons,</i> 8, (2022) Royal Society of Chemistry: 95-107. https://doi.org/10.1039/D2NH00453D.
dc.identifier.digitald2nh00453d
dc.identifier.doihttps://doi.org/10.1039/D2NH00453D
dc.identifier.urihttps://hdl.handle.net/1911/114272
dc.language.isoeng
dc.publisherRoyal Society of Chemistry
dc.rightsThis Open Access Article is licensed under a Creative Commons Attribution 3.0 Unported Licence
dc.rights.urihttps://creativecommons.org/licenses/by/3.0/
dc.titleElectrostatic polarization fields trigger glioblastoma stem cell differentiation
dc.typeJournal article
dc.type.dcmiText
dc.type.publicationpublisher version
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