Electrostatic polarization fields trigger glioblastoma stem cell differentiation

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dc.citation.firstpage95en_US
dc.citation.journalTitleNanoscale Horizonsen_US
dc.citation.lastpage107en_US
dc.citation.volumeNumber8en_US
dc.contributor.authorCabada, Tamara Fernandezen_US
dc.contributor.authorRuben, Massimoen_US
dc.contributor.authorMerhie, Amira Elen_US
dc.contributor.authorZaccaria, Remo Proiettien_US
dc.contributor.authorAlabastri, Alessandroen_US
dc.contributor.authorPetrini, Enrica Mariaen_US
dc.contributor.authorBarberis, Andreaen_US
dc.contributor.authorSalerno, Marcoen_US
dc.contributor.authorCrepaldi, Marcoen_US
dc.contributor.authorDavis, Alexanderen_US
dc.contributor.authorCeseracciu, Lucaen_US
dc.contributor.authorCatelani, Tizianoen_US
dc.contributor.authorAthanassiou, Athanassiaen_US
dc.contributor.authorPellegrino, Teresaen_US
dc.contributor.authorCingolani, Robertoen_US
dc.contributor.authorPapadopoulou, Evie L.en_US
dc.date.accessioned2023-01-27T14:47:24Zen_US
dc.date.available2023-01-27T14:47:24Zen_US
dc.date.issued2022en_US
dc.description.abstractOver the last few years it has been understood that the interface between living cells and the underlying materials can be a powerful tool to manipulate cell functions. In this study, we explore the hypothesis that the electrical cell/material interface can regulate the differentiation of cancer stem-like cells (CSCs). Electrospun polymer fibres, either polyamide 66 or poly(lactic acid), with embedded graphene nanoplatelets (GnPs), have been fabricated as CSC scaffolds, providing both the 3D microenvironment and a suitable electrical environment favorable for CSCs adhesion, growth and differentiation. We have investigated the impact of these scaffolds on the morphological, immunostaining and electrophysiological properties of CSCs extracted from human glioblastoma multiform (GBM) tumor cell line. Our data provide evidence in favor of the ability of GnP-incorporating scaffolds to promote CSC differentiation to the glial phenotype. Numerical simulations support the hypothesis that the electrical interface promotes the hyperpolarization of the cell membrane potential, thus triggering the CSC differentiation. We propose that the electrical cell/material interface can regulate endogenous bioelectrical cues, through the membrane potential manipulation, resulting in the differentiation of CSCs. Material-induced differentiation of stem cells and particularly of CSCs, can open new horizons in tissue engineering and new approaches to cancer treatment, especially GBM.en_US
dc.identifier.citationCabada, Tamara Fernandez, Ruben, Massimo, Merhie, Amira El, et al.. "Electrostatic polarization fields trigger glioblastoma stem cell differentiation." <i>Nanoscale Horizons,</i> 8, (2022) Royal Society of Chemistry: 95-107. https://doi.org/10.1039/D2NH00453D.en_US
dc.identifier.digitald2nh00453den_US
dc.identifier.doihttps://doi.org/10.1039/D2NH00453Den_US
dc.identifier.urihttps://hdl.handle.net/1911/114272en_US
dc.language.isoengen_US
dc.publisherRoyal Society of Chemistryen_US
dc.rightsThis Open Access Article is licensed under a Creative Commons Attribution 3.0 Unported Licenceen_US
dc.rights.urihttps://creativecommons.org/licenses/by/3.0/en_US
dc.titleElectrostatic polarization fields trigger glioblastoma stem cell differentiationen_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpublisher versionen_US
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