Toxicity of Quantum Dots and Cadmium Salt to Caenorhabditis elegans after Multigenerational Exposure

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dc.citation.firstpage1148en_US
dc.citation.issueNumber2en_US
dc.citation.journalTitleEnvironmental Science & Technologyen_US
dc.citation.lastpage1154en_US
dc.citation.volumeNumber47en_US
dc.contributor.authorContreras, Elizabeth Q.en_US
dc.contributor.authorCho, Minjungen_US
dc.contributor.authorZhu, Huiguangen_US
dc.contributor.authorPuppala, Hema L.en_US
dc.contributor.authorEscalera, Gabrielaen_US
dc.contributor.authorZhong, Weiweien_US
dc.contributor.authorColvin, Vicki L.en_US
dc.date.accessioned2014-10-06T17:17:58Zen_US
dc.date.available2014-10-06T17:17:58Zen_US
dc.date.issued2013en_US
dc.description.abstractTo fully understand the biological and environmental impacts of nanomaterials requires studies that address both sublethal end points and multigenerational effects. Here, we use a nematode to examine these issues as they relate to exposure to two different types of quantum dots, core (CdSe) and coreﾖshell (CdSe/ZnS), and to compare the effect to those observed after cadmium salt exposures. The strong fluorescence of the coreﾖshell QDs allowed for the direct visualization of the materials in the digestive track within a few hours of exposure. Multiple end points, including both developmental and locomotive, were examined at QD exposures of low (10 mg/L Cd), medium (50 mg/L Cd), and high concentrations (100 mg/L Cd). While the coreﾖshell QDs showed no effect on fitness (lifespan, fertility, growth, and three parameters of motility behavior), the core QDs caused acute effects similar to those found for cadmium salts, suggesting that biological effects may be attributed to cadmium leaching from the more soluble QDs. Over multiple generations, we commonly found that for lower life-cycle exposures to core QDs the parents response was generally a poor predictor of the effects on progeny. At the highest concentrations, however, biological effects found for the first generation were commonly similar in magnitude to those found in future generations.en_US
dc.identifier.citationContreras, Elizabeth Q., Cho, Minjung, Zhu, Huiguang, et al.. "Toxicity of Quantum Dots and Cadmium Salt to Caenorhabditis elegans after Multigenerational Exposure." <i>Environmental Science & Technology,</i> 47, no. 2 (2013) American Chemical Society: 1148-1154. http://dx.doi.org/10.1021/es3036785.en_US
dc.identifier.doihttp://dx.doi.org/10.1021/es3036785en_US
dc.identifier.urihttps://hdl.handle.net/1911/77391en_US
dc.language.isoengen_US
dc.publisherAmerican Chemical Societyen_US
dc.rightsThis is an author's peer-reviewed final manuscript, as accepted by the publisher. The published article is copyrighted by the American Chemical Society.en_US
dc.subject.keywordCaenorhabditis elegansen_US
dc.subject.keywordquantum dotsen_US
dc.subject.keywordmultigenerationalen_US
dc.subject.keywordtoxicityen_US
dc.subject.keywordCadmiumen_US
dc.titleToxicity of Quantum Dots and Cadmium Salt to Caenorhabditis elegans after Multigenerational Exposureen_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpost-printen_US
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