Derivatives of uncialamycin, methods of synthesis and their use as antitumor agents

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dc.contributor.assigneeRice University
dc.contributor.assigneeThe Scripps Research Institute
dc.contributor.assigneeBristol-Myers Squibb Company
dc.contributor.publisherUnited States Patent and Trademark Office
dc.creatorNicolaou, Kyriacos C.
dc.creatorLu, Min
dc.creatorMandal, Debashis
dc.creatorGangwar, Sanjeev
dc.creatorChowdari, Naidu S.
dc.creatorPoudel, Yam B.
dc.date.accessioned2019-06-19T19:43:31Z
dc.date.available2019-06-19T19:43:31Z
dc.date.filed2017-08-15
dc.date.issued2019-03-19
dc.description.abstractIn one aspect, the present disclosure provides new analogs of uncialamycin. The present disclosure also provides novel synthetic pathways to obtaining uncialamycin and analogs thereof. Additionally, the present disclosure also describes methods of use of uncialamycin and analogs thereof. In another aspect, the present disclosure provides antibody-drug conjugates which may be used to treat cancer or another disease or disorder.
dc.digitization.specificationsThis patent information was downloaded from the US Patent and Trademark website (http://www.uspto.gov/) as image-PDFs. The PDFs were OCRed for access purposes
dc.format.extent104
dc.identifier.citationNicolaou, Kyriacos C., Lu, Min, Mandal, Debashis, Gangwar, Sanjeev, Chowdari, Naidu S. and Poudel, Yam B., "Derivatives of uncialamycin, methods of synthesis and their use as antitumor agents." Patent US10233192B2. issued 2019-03-19. Retrieved from <a href="https://hdl.handle.net/1911/106108">https://hdl.handle.net/1911/106108</a>.
dc.identifier.patentIDUS10233192B2
dc.identifier.urihttps://hdl.handle.net/1911/106108
dc.language.isoeng
dc.titleDerivatives of uncialamycin, methods of synthesis and their use as antitumor agents
dc.typeUtility patent
dc.type.dcmiText
dc.type.genrepatents
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