Physical model of the immune response of bacteria against bacteriophage through the adaptive CRISPR-Cas immune system

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dc.citation.firstpage25004en_US
dc.citation.issueNumber2en_US
dc.citation.journalTitlePhysical Biologyen_US
dc.citation.volumeNumber10en_US
dc.contributor.authorHan, Puen_US
dc.contributor.authorNiestemski, Liang Renen_US
dc.contributor.authorBarrick, Jeffrey E.en_US
dc.contributor.authorDeem, Michael W.en_US
dc.date.accessioned2014-12-15T20:35:09Zen_US
dc.date.available2014-12-15T20:35:09Zen_US
dc.date.issued2013en_US
dc.description.abstractBacteria and archaea have evolved an adaptive, heritable immune system that recognizes and protects against viruses or plasmids. This system, known as the CRISPR-Cas system, allows the host to recognize and incorporate short foreign DNA or RNA sequences, called "spacers" into its CRISPR system. Spacers in the CRISPR system provide a record of the history of bacteria and phage coevolution. We use a physical model to study the dynamics of this coevolution as it evolves stochastically over time. We focus on the impact of mutation and recombination on bacteria and phage evolution and evasion. We discuss the effect of different spacer deletion mechanisms on the coevolutionary dynamics. We make predictions about bacteria and phage population growth, spacer diversity within the CRISPR locus, and spacer protection against the phage population.en_US
dc.identifier.citationHan, Pu, Niestemski, Liang Ren, Barrick, Jeffrey E., et al.. "Physical model of the immune response of bacteria against bacteriophage through the adaptive CRISPR-Cas immune system." <i>Physical Biology,</i> 10, no. 2 (2013) IOP Publishing: 25004. http://dx.doi.org/10.1088/1478-3975/10/2/025004.en_US
dc.identifier.doihttp://dx.doi.org/10.1088/1478-3975/10/2/025004en_US
dc.identifier.urihttps://hdl.handle.net/1911/78754en_US
dc.language.isoengen_US
dc.publisherIOP Publishingen_US
dc.rightsThis is an author's peer-reviewed final manuscript, as accepted by the publisher. The published article is copyrighted by IOP Publishing.en_US
dc.titlePhysical model of the immune response of bacteria against bacteriophage through the adaptive CRISPR-Cas immune systemen_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpost-printen_US
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