Physical model of the immune response of bacteria against bacteriophage through the adaptive CRISPR-Cas immune system

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dc.citation.firstpage25004
dc.citation.issueNumber2
dc.citation.journalTitlePhysical Biology
dc.citation.volumeNumber10
dc.contributor.authorHan, Pu
dc.contributor.authorNiestemski, Liang Ren
dc.contributor.authorBarrick, Jeffrey E.
dc.contributor.authorDeem, Michael W.
dc.date.accessioned2014-12-15T20:35:09Z
dc.date.available2014-12-15T20:35:09Z
dc.date.issued2013
dc.description.abstractBacteria and archaea have evolved an adaptive, heritable immune system that recognizes and protects against viruses or plasmids. This system, known as the CRISPR-Cas system, allows the host to recognize and incorporate short foreign DNA or RNA sequences, called "spacers" into its CRISPR system. Spacers in the CRISPR system provide a record of the history of bacteria and phage coevolution. We use a physical model to study the dynamics of this coevolution as it evolves stochastically over time. We focus on the impact of mutation and recombination on bacteria and phage evolution and evasion. We discuss the effect of different spacer deletion mechanisms on the coevolutionary dynamics. We make predictions about bacteria and phage population growth, spacer diversity within the CRISPR locus, and spacer protection against the phage population.
dc.identifier.citationHan, Pu, Niestemski, Liang Ren, Barrick, Jeffrey E., et al.. "Physical model of the immune response of bacteria against bacteriophage through the adaptive CRISPR-Cas immune system." <i>Physical Biology,</i> 10, no. 2 (2013) IOP Publishing: 25004. http://dx.doi.org/10.1088/1478-3975/10/2/025004.
dc.identifier.doihttp://dx.doi.org/10.1088/1478-3975/10/2/025004
dc.identifier.urihttps://hdl.handle.net/1911/78754
dc.language.isoeng
dc.publisherIOP Publishing
dc.rightsThis is an author's peer-reviewed final manuscript, as accepted by the publisher. The published article is copyrighted by IOP Publishing.
dc.titlePhysical model of the immune response of bacteria against bacteriophage through the adaptive CRISPR-Cas immune system
dc.typeJournal article
dc.type.dcmiText
dc.type.publicationpost-print
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