The endeavor of total synthesis and its impact on chemistry, biology and medicine

Simple item page
dc.citation.journalTitleNational Science Reviewen_US
dc.contributor.authorNicolaou, K.C.en_US
dc.contributor.authorHale, Christopher R.H.en_US
dc.contributor.orgBioScience Research Collaborativeen_US
dc.date.accessioned2014-04-08T13:51:07Zen_US
dc.date.available2014-04-08T13:51:07Zen_US
dc.date.issued2014en_US
dc.description.abstractThe synthesis of urea in 1828 set in motion the discipline of organic synthesis in general and of total synthesis in particular, the art and science of synthesizing natural products, the molecules of living nature. Early endeavors in total synthesis had as their main objective the proof of structure of the target molecule. Later on, the primary goal became the demonstration of the power of synthesis to construct complex molecules through appropriately devised strategies, making the endeavor an achievement whose value was measured by its elegance and efficiency. While these objectives continue to be important, contemporary endeavors in total synthesis are increasingly focused on practical aspects, including method development, efficiency, and biological and medical relevance. In this article, the emergence and evolution of total synthesis to its present state is traced, selected total syntheses from the author's laboratories are highlighted, and projections for the future of the field are discussed.en_US
dc.identifier.citationNicolaou, K.C. and Hale, Christopher R.H.. "The endeavor of total synthesis and its impact on chemistry, biology and medicine." <i>National Science Review,</i> (2014) Oxford University Press: http://dx.doi.org/10.1093/nsr/nwu001.en_US
dc.identifier.doihttp://dx.doi.org/10.1093/nsr/nwu001en_US
dc.identifier.urihttps://hdl.handle.net/1911/75842en_US
dc.language.isoengen_US
dc.publisherOxford University Pressen_US
dc.rightsArticle is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.en_US
dc.subject.keywordorganic synthesisen_US
dc.subject.keywordnatural productsen_US
dc.subject.keywordchemistryen_US
dc.subject.keywordbiologyen_US
dc.subject.keywordmedicineen_US
dc.titleThe endeavor of total synthesis and its impact on chemistry, biology and medicineen_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpublisher versionen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Nicolaou-nsr_nwu001.pdf
Size:
6.18 MB
Format:
Adobe Portable Document Format
Download
Collections
Faculty Publications
Chemistry Publications