Structural determination of Enzyme-Graphene Nanocomposite Sensor Material

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dc.citation.articleNumber15519en_US
dc.citation.journalTitleScientific Reportsen_US
dc.citation.volumeNumber9en_US
dc.contributor.authorRai, Durgesh K.en_US
dc.contributor.authorGurusaran, Manickamen_US
dc.contributor.authorUrban, Volkeren_US
dc.contributor.authorAran, Kianaen_US
dc.contributor.authorMa, Luluen_US
dc.contributor.authorQian, Shuoen_US
dc.contributor.authorNarayanan, Tharangattu N.en_US
dc.contributor.authorAjayan, Pulickel M.en_US
dc.contributor.authorLiepmann, Dorianen_US
dc.contributor.authorSekar, Kanagarajen_US
dc.contributor.authorÁlvarez-Cao, María-Efigeniaen_US
dc.contributor.authorEscuder-Rodríguez, Juan-Joséen_US
dc.contributor.authorCerdán, María-Esperanzaen_US
dc.contributor.authorGonzález-Siso, María-Isabelen_US
dc.contributor.authorViswanathan, Sowmyaen_US
dc.contributor.authorPaulmurugan, Ramasamyen_US
dc.contributor.authorRenugopalakrishnan, Venkatesanen_US
dc.contributor.authorLi, Pingzuoen_US
dc.date.accessioned2020-02-14T16:39:58Zen_US
dc.date.available2020-02-14T16:39:58Zen_US
dc.date.issued2019en_US
dc.description.abstractState-of-the-art ultra-sensitive blood glucose-monitoring biosensors, based on glucose oxidase (GOx) covalently linked to a single layer graphene (SLG), will be a valuable next generation diagnostic tool for personal glycemic level management. We report here our observations of sensor matrix structure obtained using a multi-physics approach towards analysis of small-angle neutron scattering (SANS) on graphene-based biosensor functionalized with GOx under different pH conditions for various hierarchical GOx assemblies within SLG. We developed a methodology to separately extract the average shape of GOx molecules within the hierarchical assemblies. The modeling is able to resolve differences in the average GOx dimer structure and shows that treatment under different pH conditions lead to differences within the GOx at the dimer contact region with SLG. The coupling of different analysis methods and modeling approaches we developed in this study provides a universal approach to obtain detailed structural quantifications, for establishing robust structure-property relationships. This is an essential step to obtain an insight into the structure and function of the GOx-SLG interface for optimizing sensor performance.en_US
dc.identifier.citationRai, Durgesh K., Gurusaran, Manickam, Urban, Volker, et al.. "Structural determination of Enzyme-Graphene Nanocomposite Sensor Material." <i>Scientific Reports,</i> 9, (2019) Springer Nature: https://doi.org/10.1038/s41598-019-51882-7.en_US
dc.identifier.digitals41598-019-51882-7en_US
dc.identifier.doihttps://doi.org/10.1038/s41598-019-51882-7en_US
dc.identifier.urihttps://hdl.handle.net/1911/108062en_US
dc.language.isoengen_US
dc.publisherSpringer Natureen_US
dc.rightsThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder.en_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en_US
dc.titleStructural determination of Enzyme-Graphene Nanocomposite Sensor Materialen_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpublisher versionen_US
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