Structural determination of Enzyme-Graphene Nanocomposite Sensor Material

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dc.citation.articleNumber15519
dc.citation.journalTitleScientific Reports
dc.citation.volumeNumber9
dc.contributor.authorRai, Durgesh K.
dc.contributor.authorGurusaran, Manickam
dc.contributor.authorUrban, Volker
dc.contributor.authorAran, Kiana
dc.contributor.authorMa, Lulu
dc.contributor.authorQian, Shuo
dc.contributor.authorNarayanan, Tharangattu N.
dc.contributor.authorAjayan, Pulickel M.
dc.contributor.authorLiepmann, Dorian
dc.contributor.authorSekar, Kanagaraj
dc.contributor.authorÁlvarez-Cao, María-Efigenia
dc.contributor.authorEscuder-Rodríguez, Juan-José
dc.contributor.authorCerdán, María-Esperanza
dc.contributor.authorGonzález-Siso, María-Isabel
dc.contributor.authorViswanathan, Sowmya
dc.contributor.authorPaulmurugan, Ramasamy
dc.contributor.authorRenugopalakrishnan, Venkatesan
dc.contributor.authorLi, Pingzuo
dc.date.accessioned2020-02-14T16:39:58Z
dc.date.available2020-02-14T16:39:58Z
dc.date.issued2019
dc.description.abstractState-of-the-art ultra-sensitive blood glucose-monitoring biosensors, based on glucose oxidase (GOx) covalently linked to a single layer graphene (SLG), will be a valuable next generation diagnostic tool for personal glycemic level management. We report here our observations of sensor matrix structure obtained using a multi-physics approach towards analysis of small-angle neutron scattering (SANS) on graphene-based biosensor functionalized with GOx under different pH conditions for various hierarchical GOx assemblies within SLG. We developed a methodology to separately extract the average shape of GOx molecules within the hierarchical assemblies. The modeling is able to resolve differences in the average GOx dimer structure and shows that treatment under different pH conditions lead to differences within the GOx at the dimer contact region with SLG. The coupling of different analysis methods and modeling approaches we developed in this study provides a universal approach to obtain detailed structural quantifications, for establishing robust structure-property relationships. This is an essential step to obtain an insight into the structure and function of the GOx-SLG interface for optimizing sensor performance.
dc.identifier.citationRai, Durgesh K., Gurusaran, Manickam, Urban, Volker, et al.. "Structural determination of Enzyme-Graphene Nanocomposite Sensor Material." <i>Scientific Reports,</i> 9, (2019) Springer Nature: https://doi.org/10.1038/s41598-019-51882-7.
dc.identifier.digitals41598-019-51882-7
dc.identifier.doihttps://doi.org/10.1038/s41598-019-51882-7
dc.identifier.urihttps://hdl.handle.net/1911/108062
dc.language.isoeng
dc.publisherSpringer Nature
dc.rightsThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder.
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.titleStructural determination of Enzyme-Graphene Nanocomposite Sensor Material
dc.typeJournal article
dc.type.dcmiText
dc.type.publicationpublisher version
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