In vivo Gold Nanoparticle Delivery of Peptide Vaccine Induces Anti-Tumor Immune Response in Prophylactic and Therapeutic Tumor Models

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dc.citation.firstpage1453
dc.citation.issueNumber12
dc.citation.journalTitleSmall
dc.citation.lastpage1459
dc.citation.volumeNumber11
dc.contributor.authorAlmeida, Joao Paulo Mattos
dc.contributor.authorLin, Adam Yuh
dc.contributor.authorFigueroa, Elizabeth Raquel
dc.contributor.authorFoster, Aaron Edward
dc.contributor.authorDrezek, Rebekah Anna
dc.date.accessioned2017-05-22T18:57:18Z
dc.date.available2017-05-22T18:57:18Z
dc.date.issued2015
dc.description.abstractGold nanoparticles (AuNPs) are promising vehicles for cancer immunotherapy, with demonstrated efficacy in immune delivery and innate cell stimulation. Nevertheless, their potential has yet to be assessed in the in vivo application of peptide cancer vaccines. In this study, it is hypothesized that the immune distribution and adjuvant qualities of AuNPs could be leveraged to facilitate delivery of the ovalbumin (OVA) peptide antigen and the CpG adjuvant and enhance their therapeutic effect in a B16-OVA tumor model. AuNP delivery of OVA (AuNP-OVA) and of CpG (AuNP-CpG) enhanced the efficacy of both agents and induced strong antigen-specific responses. In addition, it is found that AuNP-OVA delivery alone, without CpG, is sufficient to promote significant antigen-specific responses, leading to subsequent anti-tumor activity and prolonged survival in both prophylactic and therapeutic in vivo tumor models. This enhanced therapeutic efficacy is likely due to the adjuvant effect of peptide coated AuNPs, as they induce inflammatory cytokine release when cultured with bone marrow dendritic cells. Overall, AuNP-mediated OVA peptide delivery can produce significant therapeutic benefits without the need of adjuvant, indicating that AuNPs are effective peptide vaccine carriers with the potential to permit the use of lower and safer adjuvant doses during vaccination.
dc.identifier.citationAlmeida, Joao Paulo Mattos, Lin, Adam Yuh, Figueroa, Elizabeth Raquel, et al.. "In vivo Gold Nanoparticle Delivery of Peptide Vaccine Induces Anti-Tumor Immune Response in Prophylactic and Therapeutic Tumor Models." <i>Small,</i> 11, no. 12 (2015) Wiley: 1453-1459. http://dx.doi.org/10.1002/smll.201402179.
dc.identifier.doihttp://dx.doi.org/10.1002/smll.201402179
dc.identifier.urihttps://hdl.handle.net/1911/94334
dc.language.isoeng
dc.publisherWiley
dc.rightsThis is an author's peer-reviewed final manuscript, as accepted by the publisher. The published article is copyrighted by Wiley.
dc.subject.keywordbiodistribution
dc.subject.keywordcancer
dc.subject.keywordgold nanoparticles
dc.subject.keywordimmune system
dc.subject.keywordimmunotherapy
dc.titleIn vivo Gold Nanoparticle Delivery of Peptide Vaccine Induces Anti-Tumor Immune Response in Prophylactic and Therapeutic Tumor Models
dc.typeJournal article
dc.type.dcmiText
dc.type.publicationpost-print
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