In vivo Gold Nanoparticle Delivery of Peptide Vaccine Induces Anti-Tumor Immune Response in Prophylactic and Therapeutic Tumor Models

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dc.citation.firstpage1453en_US
dc.citation.issueNumber12en_US
dc.citation.journalTitleSmallen_US
dc.citation.lastpage1459en_US
dc.citation.volumeNumber11en_US
dc.contributor.authorAlmeida, Joao Paulo Mattosen_US
dc.contributor.authorLin, Adam Yuhen_US
dc.contributor.authorFigueroa, Elizabeth Raquelen_US
dc.contributor.authorFoster, Aaron Edwarden_US
dc.contributor.authorDrezek, Rebekah Annaen_US
dc.date.accessioned2017-05-22T18:57:18Zen_US
dc.date.available2017-05-22T18:57:18Zen_US
dc.date.issued2015en_US
dc.description.abstractGold nanoparticles (AuNPs) are promising vehicles for cancer immunotherapy, with demonstrated efficacy in immune delivery and innate cell stimulation. Nevertheless, their potential has yet to be assessed in the in vivo application of peptide cancer vaccines. In this study, it is hypothesized that the immune distribution and adjuvant qualities of AuNPs could be leveraged to facilitate delivery of the ovalbumin (OVA) peptide antigen and the CpG adjuvant and enhance their therapeutic effect in a B16-OVA tumor model. AuNP delivery of OVA (AuNP-OVA) and of CpG (AuNP-CpG) enhanced the efficacy of both agents and induced strong antigen-specific responses. In addition, it is found that AuNP-OVA delivery alone, without CpG, is sufficient to promote significant antigen-specific responses, leading to subsequent anti-tumor activity and prolonged survival in both prophylactic and therapeutic in vivo tumor models. This enhanced therapeutic efficacy is likely due to the adjuvant effect of peptide coated AuNPs, as they induce inflammatory cytokine release when cultured with bone marrow dendritic cells. Overall, AuNP-mediated OVA peptide delivery can produce significant therapeutic benefits without the need of adjuvant, indicating that AuNPs are effective peptide vaccine carriers with the potential to permit the use of lower and safer adjuvant doses during vaccination.en_US
dc.identifier.citationAlmeida, Joao Paulo Mattos, Lin, Adam Yuh, Figueroa, Elizabeth Raquel, et al.. "In vivo Gold Nanoparticle Delivery of Peptide Vaccine Induces Anti-Tumor Immune Response in Prophylactic and Therapeutic Tumor Models." <i>Small,</i> 11, no. 12 (2015) Wiley: 1453-1459. http://dx.doi.org/10.1002/smll.201402179.en_US
dc.identifier.doihttp://dx.doi.org/10.1002/smll.201402179en_US
dc.identifier.urihttps://hdl.handle.net/1911/94334en_US
dc.language.isoengen_US
dc.publisherWileyen_US
dc.rightsThis is an author's peer-reviewed final manuscript, as accepted by the publisher. The published article is copyrighted by Wiley.en_US
dc.subject.keywordbiodistributionen_US
dc.subject.keywordcanceren_US
dc.subject.keywordgold nanoparticlesen_US
dc.subject.keywordimmune systemen_US
dc.subject.keywordimmunotherapyen_US
dc.titleIn vivo Gold Nanoparticle Delivery of Peptide Vaccine Induces Anti-Tumor Immune Response in Prophylactic and Therapeutic Tumor Modelsen_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpost-printen_US
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