Assessment of spinal cord injury using ultrasound elastography in a rabbit model in vivo

Simple item page
dc.citation.articleNumber15323
dc.citation.journalTitleScientific Reports
dc.citation.volumeNumber13
dc.contributor.authorTang, Songyuan
dc.contributor.authorWeiner, Bradley
dc.contributor.authorTaraballi, Francesca
dc.contributor.authorHaase, Candice
dc.contributor.authorStetco, Eliana
dc.contributor.authorMehta, Shail Maharshi
dc.contributor.authorShajudeen, Peer
dc.contributor.authorHogan, Matthew
dc.contributor.authorDe Rosa, Enrica
dc.contributor.authorHorner, Philip J.
dc.contributor.authorGrande-Allen, K. Jane
dc.contributor.authorShi, Zhaoyue
dc.contributor.authorKarmonik, Christof
dc.contributor.authorTasciotti, Ennio
dc.contributor.authorRighetti, Raffaella
dc.date.accessioned2024-05-03T15:51:20Z
dc.date.available2024-05-03T15:51:20Z
dc.date.issued2023
dc.description.abstractThe effect of the mechanical micro-environment on spinal cord injury (SCI) and treatment effectiveness remains unclear. Currently, there are limited imaging methods that can directly assess the localized mechanical behavior of spinal cords in vivo. In this study, we apply new ultrasound elastography (USE) techniques to assess SCI in vivo at the site of the injury and at the time of one week post injury, in a rabbit animal model. Eleven rabbits underwent laminectomy procedures. Among them, spinal cords of five rabbits were injured during the procedure. The other six rabbits were used as control. Two neurological statuses were achieved: non-paralysis and paralysis. Ultrasound data were collected one week post-surgery and processed to compute strain ratios. Histologic analysis, mechanical testing, magnetic resonance imaging (MRI), computerized tomography and MRI diffusion tensor imaging (DTI) were performed to validate USE results. Strain ratios computed via USE were found to be significantly different in paralyzed versus non-paralyzed rabbits. The myelomalacia histologic score and spinal cord Young’s modulus evaluated in selected animals were in good qualitative agreement with USE assessment. It is feasible to use USE to assess changes in the spinal cord of the presented animal model. In the future, with more experimental data available, USE may provide new quantitative tools for improving SCI diagnosis and prognosis.
dc.identifier.citationTang, S., Weiner, B., Taraballi, F., Haase, C., Stetco, E., Mehta, S. M., Shajudeen, P., Hogan, M., De Rosa, E., Horner, P. J., Grande-Allen, K. J., Shi, Z., Karmonik, C., Tasciotti, E., & Righetti, R. (2023). Assessment of spinal cord injury using ultrasound elastography in a rabbit model in vivo. Scientific Reports, 13(1), 15323. https://doi.org/10.1038/s41598-023-41172-8
dc.identifier.digitals41598-023-41172-8
dc.identifier.doihttps://doi.org/10.1038/s41598-023-41172-8
dc.identifier.urihttps://hdl.handle.net/1911/115625
dc.language.isoeng
dc.publisherSpringer Nature
dc.rightsExcept where otherwise noted, this work is licensed under a Creative Commons Attribution (CC BY) license. Permission to reuse, publish, or reproduce the work beyond the terms of the license or beyond the bounds of fair use or other exemptions to copyright law must be obtained from the copyright holder.
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.titleAssessment of spinal cord injury using ultrasound elastography in a rabbit model in vivo
dc.typeJournal article
dc.type.dcmiText
dc.type.publicationpublisher version
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
s41598-023-41172-8.pdf
Size:
1.71 MB
Format:
Adobe Portable Document Format
Download
Collections
Faculty Publications
Bioengineering Publications