Assessment of spinal cord injury using ultrasound elastography in a rabbit model in vivo

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dc.citation.articleNumber15323en_US
dc.citation.journalTitleScientific Reportsen_US
dc.citation.volumeNumber13en_US
dc.contributor.authorTang, Songyuanen_US
dc.contributor.authorWeiner, Bradleyen_US
dc.contributor.authorTaraballi, Francescaen_US
dc.contributor.authorHaase, Candiceen_US
dc.contributor.authorStetco, Elianaen_US
dc.contributor.authorMehta, Shail Maharshien_US
dc.contributor.authorShajudeen, Peeren_US
dc.contributor.authorHogan, Matthewen_US
dc.contributor.authorDe Rosa, Enricaen_US
dc.contributor.authorHorner, Philip J.en_US
dc.contributor.authorGrande-Allen, K. Janeen_US
dc.contributor.authorShi, Zhaoyueen_US
dc.contributor.authorKarmonik, Christofen_US
dc.contributor.authorTasciotti, Ennioen_US
dc.contributor.authorRighetti, Raffaellaen_US
dc.contributor.orgBioengineeringen_US
dc.date.accessioned2024-05-03T15:51:20Zen_US
dc.date.available2024-05-03T15:51:20Zen_US
dc.date.issued2023en_US
dc.description.abstractThe effect of the mechanical micro-environment on spinal cord injury (SCI) and treatment effectiveness remains unclear. Currently, there are limited imaging methods that can directly assess the localized mechanical behavior of spinal cords in vivo. In this study, we apply new ultrasound elastography (USE) techniques to assess SCI in vivo at the site of the injury and at the time of one week post injury, in a rabbit animal model. Eleven rabbits underwent laminectomy procedures. Among them, spinal cords of five rabbits were injured during the procedure. The other six rabbits were used as control. Two neurological statuses were achieved: non-paralysis and paralysis. Ultrasound data were collected one week post-surgery and processed to compute strain ratios. Histologic analysis, mechanical testing, magnetic resonance imaging (MRI), computerized tomography and MRI diffusion tensor imaging (DTI) were performed to validate USE results. Strain ratios computed via USE were found to be significantly different in paralyzed versus non-paralyzed rabbits. The myelomalacia histologic score and spinal cord Young’s modulus evaluated in selected animals were in good qualitative agreement with USE assessment. It is feasible to use USE to assess changes in the spinal cord of the presented animal model. In the future, with more experimental data available, USE may provide new quantitative tools for improving SCI diagnosis and prognosis.en_US
dc.identifier.citationTang, S., Weiner, B., Taraballi, F., Haase, C., Stetco, E., Mehta, S. M., Shajudeen, P., Hogan, M., De Rosa, E., Horner, P. J., Grande-Allen, K. J., Shi, Z., Karmonik, C., Tasciotti, E., & Righetti, R. (2023). Assessment of spinal cord injury using ultrasound elastography in a rabbit model in vivo. Scientific Reports, 13(1), 15323. https://doi.org/10.1038/s41598-023-41172-8en_US
dc.identifier.digitals41598-023-41172-8en_US
dc.identifier.doihttps://doi.org/10.1038/s41598-023-41172-8en_US
dc.identifier.urihttps://hdl.handle.net/1911/115625en_US
dc.language.isoengen_US
dc.publisherSpringer Natureen_US
dc.rightsExcept where otherwise noted, this work is licensed under a Creative Commons Attribution (CC BY) license. Permission to reuse, publish, or reproduce the work beyond the terms of the license or beyond the bounds of fair use or other exemptions to copyright law must be obtained from the copyright holder.en_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en_US
dc.titleAssessment of spinal cord injury using ultrasound elastography in a rabbit model in vivoen_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpublisher versionen_US
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