Chromosomal Arrangement of Phosphorelay Genes Couples Sporulation and DNA Replication

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dc.citation.firstpage328en_US
dc.citation.issueNumber2en_US
dc.citation.journalTitleCellen_US
dc.citation.lastpage337en_US
dc.citation.volumeNumber162en_US
dc.contributor.authorNarula, Jatinen_US
dc.contributor.authorKuchina, Annaen_US
dc.contributor.authorLee, Dong-yeonen_US
dc.contributor.authorFujita, Masayaen_US
dc.contributor.authorSüel, Gürol M.en_US
dc.contributor.authorIgoshin, Oleg A.en_US
dc.contributor.orgBioengineeringen_US
dc.date.accessioned2016-10-21T17:01:00Zen_US
dc.date.available2016-10-21T17:01:00Zen_US
dc.date.issued2015en_US
dc.description.abstractGenes encoding proteins in a common regulatory network are frequently located close to one another on the chromosome to facilitate co-regulation or couple gene expression to growth rate. Contrasting with these observations, here, we demonstrate a functional role for the arrangement of Bacillus subtilis sporulation network genes on opposite sides of the chromosome. We show that the arrangement of two sporulation network genes, one located close to the origin and the other close to the terminus, leads to a transient gene dosage imbalance during chromosome replication. This imbalance is detected by the sporulation network to produce cell-cycle coordinated pulses of the sporulation master regulator Spo0A∼P. This pulsed response allows cells to decide between sporulation and continued vegetative growth during each cell cycle spent in starvation. The simplicity of this coordination mechanism suggests that it may be widely applicable in a variety of gene regulatory and stress-response settings.en_US
dc.identifier.citationNarula, Jatin, Kuchina, Anna, Lee, Dong-yeon, et al.. "Chromosomal Arrangement of Phosphorelay Genes Couples Sporulation and DNA Replication." <i>Cell,</i> 162, no. 2 (2015) Elsevier: 328-337. http://dx.doi.org/10.1016/j.cell.2015.06.012.en_US
dc.identifier.doihttp://dx.doi.org/10.1016/j.cell.2015.06.012en_US
dc.identifier.urihttps://hdl.handle.net/1911/91980en_US
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.rightsThis is an author's peer-reviewed final manuscript, as accepted by the publisher. The published article is copyrighted by Elsevier.en_US
dc.titleChromosomal Arrangement of Phosphorelay Genes Couples Sporulation and DNA Replicationen_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpost-printen_US
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