Chromosomal Arrangement of Phosphorelay Genes Couples Sporulation and DNA Replication

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dc.citation.firstpage328
dc.citation.issueNumber2
dc.citation.journalTitleCell
dc.citation.lastpage337
dc.citation.volumeNumber162
dc.contributor.authorNarula, Jatin
dc.contributor.authorKuchina, Anna
dc.contributor.authorLee, Dong-yeon
dc.contributor.authorFujita, Masaya
dc.contributor.authorSüel, Gürol M.
dc.contributor.authorIgoshin, Oleg A.
dc.date.accessioned2016-10-21T17:01:00Z
dc.date.available2016-10-21T17:01:00Z
dc.date.issued2015
dc.description.abstractGenes encoding proteins in a common regulatory network are frequently located close to one another on the chromosome to facilitate co-regulation or couple gene expression to growth rate. Contrasting with these observations, here, we demonstrate a functional role for the arrangement of Bacillus subtilis sporulation network genes on opposite sides of the chromosome. We show that the arrangement of two sporulation network genes, one located close to the origin and the other close to the terminus, leads to a transient gene dosage imbalance during chromosome replication. This imbalance is detected by the sporulation network to produce cell-cycle coordinated pulses of the sporulation master regulator Spo0A∼P. This pulsed response allows cells to decide between sporulation and continued vegetative growth during each cell cycle spent in starvation. The simplicity of this coordination mechanism suggests that it may be widely applicable in a variety of gene regulatory and stress-response settings.
dc.identifier.citationNarula, Jatin, Kuchina, Anna, Lee, Dong-yeon, et al.. "Chromosomal Arrangement of Phosphorelay Genes Couples Sporulation and DNA Replication." <i>Cell,</i> 162, no. 2 (2015) Elsevier: 328-337. http://dx.doi.org/10.1016/j.cell.2015.06.012.
dc.identifier.doihttp://dx.doi.org/10.1016/j.cell.2015.06.012
dc.identifier.urihttps://hdl.handle.net/1911/91980
dc.language.isoeng
dc.publisherElsevier
dc.rightsThis is an author's peer-reviewed final manuscript, as accepted by the publisher. The published article is copyrighted by Elsevier.
dc.titleChromosomal Arrangement of Phosphorelay Genes Couples Sporulation and DNA Replication
dc.typeJournal article
dc.type.dcmiText
dc.type.publicationpost-print
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